2026-05-17T01:16:00Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/262142025-12-18T12:53:47Zcom_20.500.12105_2327com_20.500.12105_2290col_20.500.12105_16991
Repisalud
author
Martinez-Pastor, Barbara
author
Mostoslavsky, Raul
2025-01-31T11:29:47Z
2025-01-31T11:29:47Z
2012
Front Pharmacol . 2012 Feb 21:3:22.
Front Pharmacol
22363287
https://hdl.handle.net/20.500.12105/26214
More than a decade ago, sirtuins were discovered as a highly conserved family of NAD(+)-dependent enzymes that extend lifespan in lower organisms. In mammals, sirtuins are key regulators of stress responses and metabolism, influencing a range of diseases, including diabetes, neurodegeneration, and cancer. In recent years, new functions of sirtuins have been characterized, uncovering the underlying mechanisms of their multifaceted role in metabolism. Here, we specifically review recent progress on the role of sirtuins in DNA repair and energy metabolism, further discussing the implication of sirtuins in the biology of cancer.
eng
DNA repair
SIRT1
SIRT3
SIRT6
Warburg effect
cancer metabolism
genomic instability
sirtuin biology
Sirtuins, metabolism, and cancer.
research article
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URL
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File
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2c92e7c6dabf22d1356eb58040423478
552928
application/pdf
sirtuinsmetabolismcancer-2012.pdf