2026-04-29T00:59:43Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/262112025-12-18T13:00:13Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Saez, Pablo
author
Shirke, Pallavi U
author
Seth, Jyoti R
author
Alegre-Cebollada, Jorge
author
Majumder, Abhijit
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación ProCNIC
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2025-01-30T12:43:11Z
2025-01-30T12:43:11Z
2024-12-17
Math Biosci. 2024 Dec 17:380:109362.
https://hdl.handle.net/20.500.12105/26211
39701208
Mathematical Biosciences
Cell migration regulates central life processes including embryonic development, tissue regeneration, and tumor invasion. To establish the direction of migration, cells follow exogenous cues. Durotaxis, the directed cell migration towards elastic stiffness gradients, is the classical example of mechanical taxis. However, whether gradients of the relaxation properties in the extracellular matrix may also induce tactic responses (viscotaxis) is not well understood. Moreover, whether and how durotaxis and viscotaxis interact with each other has never been investigated. Here, we integrate clutch models for cell adhesions with an active gel theory of cell migration to reveal the mechanisms that govern viscotaxis. We show that viscotaxis is enabled by an asymmetric expression of cell adhesions that further polarize the intracellular motility forces to establish the cell front, similar to durotaxis. More importantly, when both relaxation and elastic gradients coexist, durotaxis appears more efficient in controlling directed cell migration, which we confirm with experimental results. However, the presence of opposing relaxation gradients to an elastic one can arrest or shift the migration direction. Our model rationalizes for the first time the mechanisms that govern viscotaxis and its competition with durotaxis through a mathematical model.
eng
Active gel models
Cell adhesion
Clutch model
Durotaxis
Mechanotransduction
Viscotaxis
Competing elastic and viscous gradients determine directional cell migration.
research article
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URL
https://repisalud.isciii.es/bitstreams/bc75e0d7-73dd-403c-b099-9972ab010a0f/download
File
MD5
4fb13f921972ad4f9e6ed15408a4d271
2056768
application/pdf
Competing elastic and viscous_Math Biosci_2024.pdf