2026-05-04T21:52:33Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/261892025-12-18T13:01:35Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_19609col_20.500.12105_16972col_20.500.12105_16986
Repisalud
author
Domínguez, Angela
author
Avellón, Ana
author
Hernando Sebastian, Victoria
author
Soldevila, Núria
author
Borràs, Eva
author
Martínez, Ana
author
Izquierdo, Conchita
author
Torner, Núria
author
Pericas, Carles
author
Rius, Cristina
author
Godoy, Pere
funder
Centro de Investigación Biomédica en Red - CIBERESP (Epidemiología y Salud Pública)
funder
Instituto de Salud Carlos III
2025-01-29T08:56:56Z
2025-01-29T08:56:56Z
2024-11-04
Domínguez A, Avellón A, Hernando V, Soldevila N, Borràs E, Martínez A, Izquierdo C, Torner N, Pericas C, Rius C, Godoy P. Hepatitis B Virus-Related Cirrhosis and Hepatocellular Carcinoma Hospital Discharge Rates from 2005 to 2021 in Spain: Impact of Universal Vaccination. Vaccines (Basel). 2024 Nov 4;12(11):1254.
10.3390/vaccines12111254
2076-393X
Vaccines (Basel)
39591157
https://hdl.handle.net/20.500.12105/26189
Background: The main consequences of chronic hepatitis B virus (HBV) infections are cirrhosis and hepatocellular carcinoma (HCC), both associated with frequent hospitalization. The aim of this study was to analyze the impact of universal HBV vaccination in Spain on chronic HBV-related hospital discharges from 2005 to 2021. Methods: Using data from the Minimum Basic Data Set of the Spanish National Health System, we calculated the hospital discharge rate ratio (HDRR) and 95% confidence interval (CI) values for chronic HBV-related discharges between 2005 and 2021. For comparative purposes, we calculated the HDRR and 95% confidence interval (CI) values for the early (2005-2013) and later (2014-2021) periods and the vaccinated compared with unvaccinated cohorts for the 20-39 age group. Results: The hospital discharge rate per 1,000,000 people was 3.08 in 2005 and 4.50 in 2021 for HCC, and 4.81 in 2005 and 1.92 in 2021 for cirrhosis. Comparing the early and later periods, values were higher for HCC (HDRR 1.13; 95% CI: 1.06-1.20) and lower for cirrhosis (HDRR 0.56; 95% CI: 0.51-0.60). The rate for the 20-39 age group was lower for the vaccinated compared with the unvaccinated cohorts overall (HDRR 0.53; 95% CI: 0.45-0.62), for HCC (HDRR 0.66; 95% CI: 0.53-0.82), and for cirrhosis (HDRR 0.41; 95% CI: 0.33-0.53). Conclusions: This study describes the important impact, after 25 years, of universal HBV vaccination in Spain: cirrhosis hospital discharge rate was reduced, and the vaccinated cohorts, compared with the unvaccinated cohorts in the 20-39 age group, had a lower hospital discharge rate of both HCC and cirrhosis.
eng
Cirrhosis
Hepatitis B
Hepatocellular carcinoma
Impact evaluation
Vaccination
Hepatitis B Virus-Related Cirrhosis and Hepatocellular Carcinoma Hospital Discharge Rates from 2005 to 2021 in Spain: Impact of Universal Vaccination
research article
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Hepatitis_B_Virus-RelatedCirrhosis_2024.pdf
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https://repisalud.isciii.es/bitstreams/49af2dc1-850d-4772-9191-347914cf0d69/download
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Suplementary tables_Hepatitis_B_Virus-RelatedCirrhosis_2024.pdf