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oai:repisalud.isciii.es:20.500.12105/261402025-12-18T12:56:30Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608col_20.500.12105_19609

00925njm 22002777a 4500 dc Ledesma, Juan author Vicente, Diego author Pozo Sanchez, Francisco author Cilla, Gustavo author Pérez Castro, Sonia author Suárez Fernández, Jonathan author Pérez-Ruiz, Mercedes author Navarro, José María author Galán, Juan Carlos author Fernández, Mirian author Reina, Jordi author Larrauri, Amparo author Cuevas, Maria Teresa author Casas Flecha, Inmaculada author Perez-Breña, Pilar author Spanish Influenza Surveillance System (SISS) author Jimenez-Jorge, Silvia author 2011-07 Background: Pandemic influenza A (H1N1) 2009 virus appeared in Spain on April 25, 2009 for the first time. This new virus was adamantane-resistant but it was sensitive to neuraminidase (NA) inhibitors oseltamivir and zanamivir. Objectives: To detect oseltamivir-resistant pandemic influenza A (H1N1) 2009 viruses by the Spanish Influenza Surveillance System (SISS) and a possible spread of oseltamivir-resistant viruses in Spain since starting of the pandemic situation. Study design: A total of 1229 respiratory samples taken from 413 severe and 766 non-severe patients with confirmed viral detection of pandemic influenza A (H1N1) 2009 viruses from different Spanish regions were analyzed for the specific detection of the H275Y mutation in NA between April 2009 and May 2010. Results: H275Y NA substitution was found in 8 patients infected with pandemic influenza A (H1N1) 2009 viruses collected in November and December 2009 and in January 2010. All oseltamivir-resistant viruses were detected in severe patients (8/413, 1.93%) who previously received treatment with oseltamivir. Six of these patients were immunocompromised. Conclusion: In Spain, the number of oseltamivir-resistant pandemic influenza A (H1N1) 2009 viruses is until now very low. No evidence for any spread of oseltamivir-resistant H1N1 viruses is achieved in our Country. Ledesma J, Vicente D, Pozo F, Cilla G, Castro SP, Fernández JS, Ruiz MP, Navarro JM, Galán JC, Fernández M, Reina J, Larrauri A, Cuevas MT, Casas I, Breña PP; Spanish Influenza Surveillance System (SISS). Oseltamivir-resistant pandemic influenza a (H1N1) 2009 viruses in Spain. J Clin Virol. 2011 Jul;51(3):205-8. 10.1016/j.jcv.2011.04.008 1873-5967 1386-6532 Journal of clinical virology: the official publication of the Pan American Society for Clinical Virology 21592854 https://hdl.handle.net/20.500.12105/26140 Influenza Neuraminidase H275Y mutation Oseltamivir-resistance Oseltamivir-resistant pandemic influenza a (H1N1) 2009 viruses in Spain