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oai:repisalud.isciii.es:20.500.12105/261252025-12-18T12:56:33Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Rudometova, Nadezhda B author Shcherbakova, Nadezhda S author Shcherbakov, Dmitry N author Mishenova, Elena V author Delgado, Elena author Ilyichev, Alexander A author Karpenko, Larisa I author Thomson, Michael M author 2021-09 The analysis of a gene fragment encoding protease and part of reverse transcriptase was carried out for 55 sera collected in 2016 and 2018 from HIV-1-infected patients diagnosed in 2014-2018 living in the south of Western Siberia, Russia: Altai Territory ( = 11), Republic of Altai ( = 15), Kemerovo region ( = 18), and Novosibirsk region ( = 11). CRF63_02A was the dominant genetic form (>70%) in the Altai Territory and Kemerovo and Novosibirsk regions, with subsubtype A6 comprising <30% of samples. In the Altai Republic, subsubtype A6 was predominant (53%), with 33% of viruses belonging to CRF63_02A. Four CRF63_02A/A6 unique recombinant forms were identified in the Altai Territory, Kemerovo Region, and the Altai Republic. A majority (11 of 15) of CRF63_02A viruses from Kemerovo were grouped in a cluster. Antiretroviral (ARV) drug resistance mutations were found in 6 (14%) of 43 drug-naive patients. This study provides new insights in HIV-1 molecular epidemiology and prevalence of transmitted ARV drug resistance mutations in Southwestern Siberia. Rudometova NB, Shcherbakova NS, Shcherbakov DN, Mishenova EV, Delgado E, Ilyichev AA, Karpenko LI, Thomson MM. Genetic Diversity and Drug Resistance Mutations in Reverse Transcriptase and Protease Genes of HIV-1 Isolates from Southwestern Siberia. AIDS Res Hum Retroviruses. 2021 Sep;37(9):716-723. 10.1089/AID.2020.0225 1931-8405 0889-2229 AIDS research and human retroviruses 33677988 https://hdl.handle.net/20.500.12105/26125 A6 CRF63_02A HIV-1 Drug resistance Highly active antiretroviral therapy Resistance mutations Genetic Diversity and Drug Resistance Mutations in Reverse Transcriptase and Protease Genes of HIV-1 Isolates from Southwestern Siberia.