2026-04-29T22:57:46Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/260902025-12-18T12:55:51Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19610col_20.500.12105_19617

00925njm 22002777a 4500 dc Torres-Ruiz, Mónica author De la Vieja, Antonio author De Alba-González, Mercedes author Esteban-Lopez, Marta author Castaño, Argelia author Cañas Portilla, Ana Isabel author 2021-11-25 Nanoplastics (NP) are an emerging threat to human health and there is a need to understand their toxicity. Zebrafish (ZF) is extensively used as a toxicology model due to its power to com-bine genetic, cellular, and whole organism endpoints. The present review integrates results regarding polystyrene NP effects on ZF embryo development. Study design was evaluated against NP effects. NP size, concentration, and exposure time did not affect organism responses (mortality, development, heart rate, locomotion) or cellular responses (gene expression, enzymes, metabolites). However, NP accumulation depended on size. Smaller NP can reach internal organs (brain, eyes, liver, pancreas, heart) but larger (>200 nm) accumulate mainly in gut, gills and skin. Locomotion and heart rate were commonly affected with hypoactivity and bradycardia being more prevalent. Effects on genetic/enzymatic/metabolic pathways were thoroughly analyzed. Immunity genes were generally upregulated whereas oxidative stress response genes varied. Central nervous system genes and visual related genes were generally downregulated. Results of genetic and enzymatic analyses coincided only for some genes/enzyme pairs. Reviewed studies provide a basis for understanding NP toxicity but results are hard to integrate. We propose key recommendations and future directions with regard to experimental design that may allow greater comparability across future studies. Torres-Ruiz M, De la Vieja A, de Alba Gonzalez M, Esteban Lopez M, Castaño Calvo A, Cañas Portilla AI. Toxicity of nanoplastics for zebrafish embryos, what we know and where to go next. Sci Total Environ. 2021 Nov 25;797:149125. 10.1016/j.scitotenv.2021.149125 1879-1026 0048-9697 The Science of the total environment 34346375 https://hdl.handle.net/20.500.12105/26090 Danio rerio Nanoparticles Plastic Polystyrene Toxicology Toxicity of nanoplastics for zebrafish embryos, what we know and where to go next