2026-04-26T23:12:01Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/260772025-12-18T12:54:09Zcom_20.500.12105_2327com_20.500.12105_2290col_20.500.12105_16991
Repisalud
author
Hernández-Barranco, Alberto
author
Nogués, Laura
author
Peinado Selgas, Hector
funder
La Caixa Foundation
funder
Fundacion Ramon Areces
2025-01-20T16:19:56Z
2025-01-20T16:19:56Z
2021
Front Cell Dev Biol . 2021 Mar 2:9:625221
https://hdl.handle.net/20.500.12105/26077
33738282
Front Cell Dev Biol
Pre-metastatic niches provide favorable conditions for tumor cells to disseminate, home to and grow in otherwise unfamiliar and distal microenvironments. Tumor-derived extracellular vesicles are now recognized as carriers of key messengers secreted by primary tumors, signals that induce the formation of pre-metastatic niches. Recent evidence suggests that tumor cells can disseminate from the very earliest stages of primary tumor development. However, once they reach distal sites, tumor cells can persist in a dormant state for long periods of time until their growth is reactivated and they produce metastatic lesions. In this new scenario, the question arises as to whether extracellular vesicles could influence the formation of these metastatic niches with dormant tumor cells? (here defined as "sleepy niches"). If so, what are the molecular mechanisms involved? In this perspective-review article, we discuss the possible influence of extracellular vesicles in early metastatic dissemination and whether they might play a role in tumor cell dormancy. In addition, we comment whether extracellular vesicle-mediated signals may be involved in tumor cell awakening, considering the possibility that extracellular vesicles might serve as biomarkers to detect early metastasis and/or minimal residual disease (MRD) monitoring.
eng
disseminated tumor cells
dormancy
exosome
extracellular vesicle
metastasis
Could Extracellular Vesicles Contribute to Generation or Awakening of "Sleepy" Metastatic Niches?
research article
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URL
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7bc87d178fca32325d2221a6c433b2db
1785032
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couldextracellular-2021.pdf