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oai:repisalud.isciii.es:20.500.12105/260772025-12-18T12:54:09Zcom_20.500.12105_2327com_20.500.12105_2290col_20.500.12105_16991

00925njm 22002777a 4500 dc Hernández-Barranco, Alberto author Nogués, Laura author Peinado Selgas, Hector author 2021 Pre-metastatic niches provide favorable conditions for tumor cells to disseminate, home to and grow in otherwise unfamiliar and distal microenvironments. Tumor-derived extracellular vesicles are now recognized as carriers of key messengers secreted by primary tumors, signals that induce the formation of pre-metastatic niches. Recent evidence suggests that tumor cells can disseminate from the very earliest stages of primary tumor development. However, once they reach distal sites, tumor cells can persist in a dormant state for long periods of time until their growth is reactivated and they produce metastatic lesions. In this new scenario, the question arises as to whether extracellular vesicles could influence the formation of these metastatic niches with dormant tumor cells? (here defined as "sleepy niches"). If so, what are the molecular mechanisms involved? In this perspective-review article, we discuss the possible influence of extracellular vesicles in early metastatic dissemination and whether they might play a role in tumor cell dormancy. In addition, we comment whether extracellular vesicle-mediated signals may be involved in tumor cell awakening, considering the possibility that extracellular vesicles might serve as biomarkers to detect early metastasis and/or minimal residual disease (MRD) monitoring. Front Cell Dev Biol . 2021 Mar 2:9:625221 https://hdl.handle.net/20.500.12105/26077 33738282 Front Cell Dev Biol disseminated tumor cells dormancy exosome extracellular vesicle metastasis Could Extracellular Vesicles Contribute to Generation or Awakening of "Sleepy" Metastatic Niches?