2026-05-20T04:15:54Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/260702025-12-18T12:55:43Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609col_20.500.12105_25179
Repisalud
author
Gutiérrez-López, Rafael
author
Ruiz-López, María José
author
Ledesma, Juan
author
Ledesma, Juan
author
Magallanes, Sergio
author
Nieto, Cristina
author
Ruiz, Santiago
author
Sánchez-Peña, Carolina
author
Ameyugo, Ulises
author
Camacho, Juan
author
Varona Fernandez, Sarai
author
Cuesta de la Plaza, Isabel
author
Jado, Isabel
author
Sánchez-Seco, María Paz
author
Figuerola, Jordi
author
Vazquez, Ana
funder
Agencia Estatal de Investigación (España)
funder
Ministerio de Ciencia e Innovación (España)
funder
Unión Europea. Comisión Europea. NextGenerationEU
funder
Regional Government of Andalusia (España)
funder
Instituto de Salud Carlos III
2025-01-20T12:38:10Z
2025-01-20T12:38:10Z
2025
Gutiérrez-López R, Ruiz-López MJ, Ledesma J, Magallanes S, Nieto C, Ruiz S, Sanchez-Peña C, Ameyugo U, Camacho J, Varona S, Cuesta I, Jado-García I, Sanchez-Seco MP, Figuerola J, Vázquez A. First isolation of the Sindbis virus in mosquitoes from southwestern Spain reveals a new recent introduction from Africa. One Health. 2025;20:100947.
10.1016/j.onehlt.2024.100947
2352-7714
One health
39760017
https://hdl.handle.net/20.500.12105/26070
Sindbis virus (SINV), is an of the family . This zoonotic arbovirus is transmitted by mosquitoes, primarily from the genus, with bird species acting as amplifying vertebrate hosts. Occasionally it can also affect humans that are accidental hosts. SINV genotype I (SINV-I) has been isolated in mosquitoes and birds in South Africa and Northern Europe, producing fever outbreaks. In the last decades, there were several detections of SINV in Europe. In 2022, during the West Nile virus (WNV) mosquito surveillance program in Andalucía (Spain) implemented by the regional health administration, we detected the presence of both SINV and WNV in a pool, representing the first detection of SINV in Spain. After this finding, we screened 1149 mosquito pools to determine the status of SINV circulation in western Andalucía. We identified for the first time the presence of SINV in five different mosquito species. presented the highest infection rate by SINV. In addition, SINV was geographically widespread and distributed in four out of the five Andalucía's provinces studied, with Cadiz presenting the highest infection rate. All SINV genomes from Southwestern Spain characterised in this study belonged to SINV-I, previously detected in Europe and Africa. These isolated SINV-I strains presented low molecular variation among them and in the phylogenomic analyses they formed a monophyletic group that clustered with strains from Algeria and Kenya. These results suggest that, around 2017, a single new SINV introduction into the European continent occurred, probably from Northern (Algeria) or Central Africa.
eng
Alphavirus
Arbovirus
Culex
Next generation sequencing
One health
Vector-borne diseases
First isolation of the Sindbis virus in mosquitoes from southwestern Spain reveals a new recent introduction from Africa
research article
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https://repisalud.isciii.es/bitstreams/d3d2917e-6a7a-4a33-a720-85476f712ff8/download
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FirstIsolationSindbisVirusMosquitoes_2025.pdf
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https://repisalud.isciii.es/bitstreams/c9747364-3236-4d03-ba2d-90f1c4f449e3/download
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Supplementary_FirstIsolationSindbisVirusMosquitoes_2025.pdf