2026-05-20T04:15:53Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/260702025-12-18T12:55:43Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609col_20.500.12105_25179

00925njm 22002777a 4500 dc Gutiérrez-López, Rafael author Ruiz-López, María José author Ledesma, Juan author Ledesma, Juan author Magallanes, Sergio author Nieto, Cristina author Ruiz, Santiago author Sánchez-Peña, Carolina author Ameyugo, Ulises author Camacho, Juan author Varona Fernandez, Sarai author Cuesta de la Plaza, Isabel author Jado, Isabel author Sánchez-Seco, María Paz author Figuerola, Jordi author Vazquez, Ana author 2025 Sindbis virus (SINV), is an of the family . This zoonotic arbovirus is transmitted by mosquitoes, primarily from the genus, with bird species acting as amplifying vertebrate hosts. Occasionally it can also affect humans that are accidental hosts. SINV genotype I (SINV-I) has been isolated in mosquitoes and birds in South Africa and Northern Europe, producing fever outbreaks. In the last decades, there were several detections of SINV in Europe. In 2022, during the West Nile virus (WNV) mosquito surveillance program in Andalucía (Spain) implemented by the regional health administration, we detected the presence of both SINV and WNV in a pool, representing the first detection of SINV in Spain. After this finding, we screened 1149 mosquito pools to determine the status of SINV circulation in western Andalucía. We identified for the first time the presence of SINV in five different mosquito species. presented the highest infection rate by SINV. In addition, SINV was geographically widespread and distributed in four out of the five Andalucía's provinces studied, with Cadiz presenting the highest infection rate. All SINV genomes from Southwestern Spain characterised in this study belonged to SINV-I, previously detected in Europe and Africa. These isolated SINV-I strains presented low molecular variation among them and in the phylogenomic analyses they formed a monophyletic group that clustered with strains from Algeria and Kenya. These results suggest that, around 2017, a single new SINV introduction into the European continent occurred, probably from Northern (Algeria) or Central Africa. Gutiérrez-López R, Ruiz-López MJ, Ledesma J, Magallanes S, Nieto C, Ruiz S, Sanchez-Peña C, Ameyugo U, Camacho J, Varona S, Cuesta I, Jado-García I, Sanchez-Seco MP, Figuerola J, Vázquez A. First isolation of the Sindbis virus in mosquitoes from southwestern Spain reveals a new recent introduction from Africa. One Health. 2025;20:100947. 10.1016/j.onehlt.2024.100947 2352-7714 One health 39760017 https://hdl.handle.net/20.500.12105/26070 Alphavirus Arbovirus Culex Next generation sequencing One health Vector-borne diseases First isolation of the Sindbis virus in mosquitoes from southwestern Spain reveals a new recent introduction from Africa