2026-04-29T02:37:44Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/260562025-12-18T13:00:39Zcom_20.500.12105_19586com_20.500.12105_2202col_20.500.12105_19587
Repisalud
author
Tirozzi, Alfonsina
author
Izzi, Benedetta
author
Noro, Fabrizia
author
Marotta, Annalisa
author
Gianfagna, Francesco
author
Hoylaerts, Marc F
author
Cerletti, Chiara
author
Donati, Maria Benedetta
author
de Gaetano, Giovanni
author
Iacoviello, Licia
author
Gialluisi, Alessandro
2025-01-17T14:28:36Z
2025-01-17T14:28:36Z
2020-10-07
Front Immunol. 2020 Oct 7:11:02127.
https://hdl.handle.net/20.500.12105/26056
33117333
Frontiers in Immunology
Neurodegenerative disorders such as Parkinson's disease (PD) and Alzheimer's disease (AD) suffer from the lack of risk-predictive circulating biomarkers, and clinical diagnosis occurs only when symptoms are evident. Among potential biomarkers, platelet parameters have been associated with both disorders. However, these associations have been scarcely investigated at the genetic level. Here, we tested genome-wide coheritability based on common genetic variants between platelet parameters and PD/AD risk, through Linkage Disequilibrium Score Regression. This revealed a significant genetic correlation between platelet distribution width (PDW), an index of platelet size variability, and PD risk (r [SE] = 0.080 [0.034]; p = 0.019), which was confirmed by a summary-summary polygenic score analysis, where PDW explained a small but significant proportion PD risk (<1%). AD risk showed no significant correlations, although a negative trend was observed with PDW (rg [SE] =-0.088 [0.053]; p=0.096), in line with previous epidemiological reports. These findings suggest the existence of limited shared genetic bases between PDW and PD and warrant further investigations to clarify the genes involved in this relation. Additionally, they suggest that the association between platelet parameters and AD risk is more environmental in nature, prompting an investigation into which factors may influence these traits.
eng
Alzheimer disease
Parkinson disease
genetic correlation
genetics
neurodegenerative disorders
platelet distribution width
platelets
Assessing Genetic Overlap Between Platelet Parameters and Neurodegenerative Disorders.
research article
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Assessing Genetic_Front Immunol_2020.pdf