2026-04-29T04:10:24Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/260432025-12-18T13:01:24Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Izzi, Benedetta
author
Tirozzi, Alfonsina
author
Cerletti, Chiara
author
Donati, Maria Benedetta
author
de Gaetano, Giovanni
author
Hoylaerts, Marc F
author
Iacoviello, Licia
author
Gialluisi, Alessandro
funder
Marie Curie
funder
Unión Europea. Comisión Europea. H2020
funder
Fondazione Umberto Veronesi
funder
Fundación Pfizer
2025-01-17T09:27:10Z
2025-01-17T09:27:10Z
2020-11-21
Int J Mol Sci. 2020 Nov 21;21(22):8817.
https://hdl.handle.net/20.500.12105/26043
33233416
International Journal of Molecular Sciences
Alongside their function in primary haemostasis and thrombo-inflammation, platelets are increasingly considered a bridge between mental, immunological and coagulation-related disorders. This review focuses on the link between platelets and the pathophysiology of major depressive disorder (MDD) and its most frequent comorbidities. Platelet- and neuron-shared proteins involved in MDD are functionally described. Platelet-related studies performed in the context of MDD, cardiovascular disease, and major neurodegenerative, neuropsychiatric and neurodevelopmental disorders are transversally presented from an epidemiological, genetic and functional point of view. To provide a complete scenario, we report the analysis of original data on the epidemiological link between platelets and depression symptoms suggesting moderating and interactive effects of sex on this association. Epidemiological and genetic studies discussed suggest that blood platelets might also be relevant biomarkers of MDD prediction and occurrence in the context of MDD comorbidities. Finally, this review has the ambition to formulate some directives and perspectives for future research on this topic.
eng
cardiovascular disease
depression
gender
neurodegenerative disorders
platelet distribution width
platelets
psychiatric comorbidities
Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities.
review
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URL
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Beyond Haemostasis and Thrombosis_Int J Mol Sci_2020.pdf