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oai:repisalud.isciii.es:20.500.12105/260412025-12-18T12:56:02Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19616

00925njm 22002777a 4500 dc Politis, Maria D author Bermejo-Sanchez, Eva author Canfield, Mark A author Contiero, Paolo author Cragan, Janet D author Dastgiri, Saeed author de Walle, Hermien E K author Feldkamp, Marcia L author Nance, Amy author Groisman, Boris author Gatt, Miriam author Benavides-Lara, Adriana author Hurtado-Villa, Paula author Källén Kärin author Landau, Danielle author Lelong, Nathalie author Lopez-Camelo, Jorge author Martinez, Laura author Morgan, Margery author Mutchinick, Osvaldo M author Pierini, Anna author Rissmann, Anke author Šípek, Antonin author Szabova, Elena author Wertelecki, Wladimir author Zarante, Ignacio author Bakker, Marian K author Kancherla, Vijaya author Mastroiacovo, Pierpaolo author Nembhard, Wendy N author International Clearinghouse for Birth Defects Surveillance and Research author 2021-04 Purpose: This study determined the prevalence, mortality, and time trends of children with congenital diaphragmatic hernia (CDH). Methods: Twenty-five hospital- and population-based surveillance programs in 19 International Clearinghouse for Birth Defects Surveillance and Research member countries provided birth defects mortality data between 1974 and 2015. CDH cases included live births, stillbirths, or elective termination of pregnancy for fetal anomalies. Prevalence, cumulative mortality rates, and 95% confidence intervals (CIs) were calculated using Poisson regression and a Kaplan-Meier product-limit method. Joinpoint regression analyses were conducted to assess time trends. Results: The prevalence of CDH was 2.6 per 10,000 total births (95% CI: 2.5-2.7), slightly increasing between 2001 and 2012 (average annual percent change = 0.5%; 95% CI:-0.6 to 1.6). The total percent mortality of CDH was 37.7%, with hospital-based registries having more deaths among live births than population-based registries (45.1% vs. 33.8%). Mortality rates decreased over time (average annual percent change = -2.4%; 95% CI: -3.8 to 1.1). Most deaths due to CDH occurred among 2- to 6-day-old infants for both registry types (36.3%, hospital-based; 12.1%, population-based). Conclusions: The mortality of CDH has decreased over time. Mortality remains high during the first week and varied by registry type. Politis MD, Bermejo-Sánchez E, Canfield MA, Contiero P, Cragan JD, Dastgiri S, de Walle HEK, Feldkamp ML, Nance A, Groisman B, Gatt M, Benavides-Lara A, Hurtado-Villa P, Kallén K, Landau D, Lelong N, Lopez-Camelo J, Martinez L, Morgan M, Mutchinick OM, Pierini A, Rissmann A, Šípek A, Szabova E, Wertelecki W, Zarante I, Bakker MK, Kancherla V, Mastroiacovo P, Nembhard WN; International Clearinghouse for Birth Defects Surveillance and Research. Prevalence and mortality in children with congenital diaphragmatic hernia: a multicountry study. Ann Epidemiol. 2021 Apr;56:61-69.e3. 10.1016/j.annepidem.2020.11.007 1873-2585 1047-2797 Annals of epidemiology https://pmc.ncbi.nlm.nih.gov/articles/PMC8009766/ 33253899 https://hdl.handle.net/20.500.12105/26041 Hospital-based Mortality Population-based Prevalence Registry Prevalence and mortality in children with congenital diaphragmatic hernia: a multicountry study.