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oai:repisalud.isciii.es:20.500.12105/260352025-12-18T12:55:43Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19616

00925njm 22002777a 4500 dc Yu, Xiao author Nassar, Natasha author Mastroiacovo, Pierpaolo author Canfield, Mark author Groisman, Boris author Bermejo-Sanchez, Eva author Ritvanen, Annukka author Kiuru-Kuhlefelt, Sonja author Benavides, Adriana author Sipek, Antonin author Pierini, Anna author Bianchi, Fabrizio author Källén Kärin author Gatt, Miriam author Morgan, Margery author Tucker, David author Canessa, M Aaurora author Gajardo, Rosa author Mutchinick, Osvaldo M author Szabova, Elena author Csáky-Szunyogh, Melinda author Tagliabue, Giovanna author Cragan, Janet D author Nembhard, Wendy N author Rissmann, Anke author Goetz, Dorit author Bower, Carol author Baynam, Gareth author Lowry, R Brian author Leon, Juan A author Luo, Wei author Rouleau, Jocelyn author Zarante, Ignacio author Fernandez, Nicolas author Amar, Emmanuelle author Dastgiri, Saeed author Contiero, Paolo author Martínez-de-Villarreal, Laura E author Borman, Barry author Bergman, Jorieke EH author de Walle, Hermien E K author Hobbs, Charlotte A author Nance, Amy E author Agopian, A J author 2019-10 Background: Hypospadias is a common male birth defect that has shown widespread variation in reported prevalence estimates. Many countries have reported increasing trends over recent decades. Objective: To analyze the prevalence and trends of hypospadias for 27 international programs over a 31-yr period. Design, setting, and participants: The study population included live births, stillbirths, and elective terminations of pregnancy diagnosed with hypospadias during 1980-2010 from 27 surveillance programs around the world. Outcome measurements and statistical analysis: We used joinpoint regression to analyze changes over time in international total prevalence of hypospadias across programs, prevalence for each specific program, and prevalence across different degrees of severity of hypospadias. Results and limitations: The international total prevalence of hypospadias for all years was 20.9 (95% confidence interval: 19.2-22.6) per 10000 births. The prevalence for each program ranged from 2.1 to 39.1 per 10000 births. The international total prevalence increased 1.6 times during the study period, by 0.25 cases per 10000 births per year (p<0.05). When analyzed separately, there were increasing trends for first-, second-, and third-degree hypospadias during the early 1990s to mid-2000s. The majority of programs (61.9%) had a significantly increasing trend during many of the years evaluated. Limitations include known differences in data collection methods across programs. Conclusions: Although there have been changes in clinical practice and registry ascertainment over time in some countries, the consistency in the observed increasing trends across many programs and by degrees of severity suggests that the total prevalence of hypospadias may be increasing in many countries. This observation is contrary to some previous reports that suggested that the total prevalence of hypospadias was no longer increasing in recent decades. Patient summary: We report on the prevalence and trends of hypospadias among 27 birth defect surveillance systems, which indicate that the prevalence of hypospadias continues to increase internationally. Yu X, Nassar N, Mastroiacovo P, Canfield M, Groisman B, Bermejo-Sánchez E, Ritvanen A, Kiuru-Kuhlefelt S, Benavides A, Sipek A, Pierini A, Bianchi F, Källén K, Gatt M, Morgan M, Tucker D, Canessa MA, Gajardo R, Mutchinick OM, Szabova E, Csáky-Szunyogh M, Tagliabue G, Cragan JD, Nembhard WN, Rissmann A, Goetz D, Bower C, Baynam G, Lowry RB, Leon JA, Luo W, Rouleau J, Zarante I, Fernandez N, Amar E, Dastgiri S, Contiero P, Martínez-de-Villarreal LE, Borman B, Bergman JEH, de Walle HEK, Hobbs CA, Nance AE, Agopian AJ. Hypospadias Prevalence and Trends in International Birth Defect Surveillance Systems, 1980-2010. Eur Urol. 2019 Oct;76(4):482-490. 10.1016/j.eururo.2019.06.027 1873-7560 0302-2838 European urology https://pmc.ncbi.nlm.nih.gov/articles/PMC7265200/ 31300237 https://hdl.handle.net/20.500.12105/26035 Hypospadias International Clearinghouse for Birth Defects Surveillance and Research Joinpoint regression Prevalence Trend Hypospadias Prevalence and Trends in International Birth Defect Surveillance Systems, 1980-2010.