2026-06-14T03:32:58Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/260092025-12-18T12:56:55Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Calsina, Bruna author Piñeiro-Yáñez, Elena author Martínez-Montes, Ángel M author Caleiras, Eduardo author Fernández-Sanromán, Ángel author Monteagudo, María author Torres-Pérez, Rafael author Fustero-Torre, Coral author Pulgarín-Alfaro, Marta author Gil, Eduardo author Letón, Rocío author Jiménez, Scherezade author García-Martín, Santiago author Martin, Maria Carmen author Roldán-Romero, Juan María author Lanillos, Javier author Mellid, Sara author Santos, María author Díaz-Talavera, Alberto author Rubio, Ángeles author González, Patricia author Hernando, Barbara author Bechmann, Nicole author Dona, Margo author Calatayud, María author Guadalix, Sonsoles author Álvarez-Escolá, Cristina author Regojo, Rita M author Aller, Javier author Del Olmo-Garcia, Maria Isabel author López-Fernández, Adrià author Fliedner, Stephanie M J author Rapizzi, Elena author Fassnacht, Martin author Beuschlein, Felix author Quinkler, Marcus author Toledo, Rodrigo A author Mannelli, Massimo author Timmers, Henri J author Eisenhofer, Graeme author Rodriguez Perales, Sandra author Domínguez, Orlando author Macintyre, Geoffrey author Currás-Freixes, Maria author Rodríguez-Antona, Cristina author Cascón, Alberto author Leandro-García, Luis J author Roncador, Giovanna author García-García, Juan Fernando author Pacak, Karel author Al-Shahrour, Fatima author Robledo Batanero, Mercedes author 2023-02-28 The mechanisms triggering metastasis in pheochromocytoma/paraganglioma are unknown, hindering therapeutic options for patients with metastatic tumors (mPPGL). Herein we show by genomic profiling of a large cohort of mPPGLs that high mutational load, microsatellite instability and somatic copy-number alteration burden are associated with ATRX/TERT alterations and are suitable prognostic markers. Transcriptomic analysis defines the signaling networks involved in the acquisition of metastatic competence and establishes a gene signature related to mPPGLs, highlighting CDK1 as an additional mPPGL marker. Immunogenomics accompanied by immunohistochemistry identifies a heterogeneous ecosystem at the tumor microenvironment level, linked to the genomic subtype and tumor behavior. Specifically, we define a general immunosuppressive microenvironment in mPPGLs, the exception being PD-L1 expressing MAML3-related tumors. Our study reveals canonical markers for risk of metastasis, and suggests the usefulness of including immune parameters in clinical management for PPGL prognostication and identification of patients who might benefit from immunotherapy. Nat Commun . 2023 Feb 28;14(1):1122. Nature Communications 36854674 https://hdl.handle.net/20.500.12105/26009 SOMATIC MUTATIONS MICROSATELLITE INSTABILITY COMPREHENSIVE ANALYSIS RIBOSOME BIOGENESIS TERT PROMOTER CELL CYCLE CANCER TUMORS RNA ACTIVATION Genomic and immune landscape Of metastatic pheochromocytoma and paraganglioma.