2026-05-22T00:44:30Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/260032025-12-18T12:55:56Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608col_20.500.12105_19609
Repisalud
author
Gavilán, Ana M
author
Díez-Fuertes, Francisco
author
Sanz, J C
author
Castellanos-Nadal, Ana Maria
author
Lopez-Perea, Noemi
author
Jiménez, S M
author
Ruiz-Sopeña, C
author
Masa-Calles, Josefa
author
García-Comas, L
author
De Ory, Fernando de
author
Perez-Olmeda, Mayte
author
Fernandez-Garcia, Aurora
author
Echevarria, Juan Emilio
funder
Instituto de Salud Carlos III
funder
Centro de Investigación Biomédica en Red - CIBERESP (Epidemiología y Salud Pública)
2025-01-13T11:26:02Z
2025-01-13T11:26:02Z
2022-12-28
Gavilán AM, Díez-Fuertes F, Sanz JC, Castellanos AM, López-Perea N, Jiménez SM, Ruiz-Sopeña C, Masa-Calles J, García-Comas L, de Ory F, Pérez-Olmeda M, Fernández-García A, Echevarría JE. Increase of Diversity of Mumps Virus Genotype G SH Variants Circulating Among a Highly Immunized Population: Spain, 2007-2019. J Infect Dis. 2022 Dec 28;227(1):151-160.
10.1093/infdis/jiac176
1537-6613
0022-1899
The Journal of infectious diseases
35524966
https://hdl.handle.net/20.500.12105/26003
MuV caused three epidemic waves in Spain since genotype G emerged in 2005, despite high vaccination coverage. SH gene sequencing according to WHO protocols allowed the identification of seven relevant variants and 88 haplotypes. While the originally imported MuVi/Sheffield.GBR/1.05/-variant prevailed during the first two waves, it was subsequently replaced by other variants originated by either local evolution or importation, according to the additional analysis of hypervariable NCRs. The time of emergence of the MRCA of each MuV variant clade was concordant with the data of the earliest sequence. The analysis of Shannon entropy showed an accumulation of variability on six particular positions as the cause of the increase on the number of circulating SH variants. Consequently, SH gene sequencing needs to be complemented with other more variable markers for mumps surveillance immediately after the emergence of a new genotype, but the subsequent emergence of new SH variants turns it unnecessary.
eng
SH variants
Laboratory surveillance
Molecular epidemiology
Mumps
Mumps virus
Increase of Diversity of Mumps Virus Genotype G SH Variants Circulating Among a Highly Immunized Population: Spain, 2007-2019
research article
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Supplementary_data_IncreaseDiversityMumpsVirusGenotype_2022.pdf