2026-07-21T11:11:20Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/260032025-12-18T12:55:56Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608col_20.500.12105_19609

00925njm 22002777a 4500 dc Gavilán, Ana M author Díez-Fuertes, Francisco author Sanz, J C author Castellanos-Nadal, Ana Maria author Lopez-Perea, Noemi author Jiménez, S M author Ruiz-Sopeña, C author Masa-Calles, Josefa author García-Comas, L author De Ory, Fernando de author Perez-Olmeda, Mayte author Fernandez-Garcia, Aurora author Echevarria, Juan Emilio author 2022-12-28 MuV caused three epidemic waves in Spain since genotype G emerged in 2005, despite high vaccination coverage. SH gene sequencing according to WHO protocols allowed the identification of seven relevant variants and 88 haplotypes. While the originally imported MuVi/Sheffield.GBR/1.05/-variant prevailed during the first two waves, it was subsequently replaced by other variants originated by either local evolution or importation, according to the additional analysis of hypervariable NCRs. The time of emergence of the MRCA of each MuV variant clade was concordant with the data of the earliest sequence. The analysis of Shannon entropy showed an accumulation of variability on six particular positions as the cause of the increase on the number of circulating SH variants. Consequently, SH gene sequencing needs to be complemented with other more variable markers for mumps surveillance immediately after the emergence of a new genotype, but the subsequent emergence of new SH variants turns it unnecessary. Gavilán AM, Díez-Fuertes F, Sanz JC, Castellanos AM, López-Perea N, Jiménez SM, Ruiz-Sopeña C, Masa-Calles J, García-Comas L, de Ory F, Pérez-Olmeda M, Fernández-García A, Echevarría JE. Increase of Diversity of Mumps Virus Genotype G SH Variants Circulating Among a Highly Immunized Population: Spain, 2007-2019. J Infect Dis. 2022 Dec 28;227(1):151-160. 10.1093/infdis/jiac176 1537-6613 0022-1899 The Journal of infectious diseases 35524966 https://hdl.handle.net/20.500.12105/26003 SH variants Laboratory surveillance Molecular epidemiology Mumps Mumps virus Increase of Diversity of Mumps Virus Genotype G SH Variants Circulating Among a Highly Immunized Population: Spain, 2007-2019