2026-08-29T10:33:19Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/259952025-12-18T13:01:03Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Manzano, María Dolores
author
Cereza, Javier
author
García, Jesús
author
Yus, Luis Javier
author
Badiola, Juan José
author
Echevarria, Juan Emilio
author
Monzón, Marta
funder
Gobierno de Aragón (España)
2025-01-10T16:22:24Z
2025-01-10T16:22:24Z
2024-03-11
Manzano MD, Cereza J, García J, Yus LJ, Badiola JJ, Echevarria JE, Monzón M. Factors Involved in the Immunological Protection against Rabies Virus in Dogs in Spain. Vaccines (Basel). 2024 Mar 11;12(3):293. doi: 10.3390/vaccines12030293.
10.3390/vaccines12030293
2076-393X
Vaccines (Basel)
38543927
https://hdl.handle.net/20.500.12105/25995
Rabies, a viral disease spread by infected animal bites that causes encephalitis in humans and other mammals, is a neglected infectious disease present on all continents except Antarctica. Spain has been free of terrestrial rabies since 1978. However, due to its geographical situation, it represents a bridge for imported cases from an endemic continent such as Africa to Europe. Rabies vaccination in dogs is an essential preventive tool against this zoonosis. The aim of this study was to determine the state of the immune response against rabies virus in dogs in Spain and to demonstrate whether several factors that have been previously related to the influence of the seroprevalence of this species are involved here. The seroconversion level of this zoonotic virus was assessed in a total of 1060 animals. Indirect ELISA was used to obtain data for statistical analysis to evaluate the studied variables. Working under the concept of One Health, this study provides relevant information to be taken into consideration not only to prevent re-emergence in countries free of this disease but also for prevention and control in endemic countries.
eng
One Health
Factors affecting seroprevalence
Immune protection against rabies virus in dogs
Rabies vaccine
Serum antibodies
Factors Involved in the Immunological Protection against Rabies Virus in Dogs in Spain
research article
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FactorsInvolvedImmunologicalProtection_2024.pdf