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oai:repisalud.isciii.es:20.500.12105/259772025-12-18T13:00:57Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Vela, Ana Isabel author Villalón, Pilar author Saez-Nieto, Juan Antonio author Chacón, Gema author Domínguez, Lucas author Fernández-Garayzábal, José Francisco author 2017-12 Streptococcus pyogenes appears to be almost exclusively restricted to humans, with few reports on isolation from animals. We provide a detailed characterization (emm typing, pulsed-field gel electrophoresis [PFGE], and multilocus sequence typing [MLST]) of 15 S. pyogenes isolates from animals associated with different clinical backgrounds. We also investigated erythromycin resistance mechanisms and phenotypes and virulence genes. We observed 2 emm types: emm12 (11 isolates) and emm77 (4 isolates). Similarly, we observed 2 genetic linages, sequence type (ST) 26 and ST63. Most isolates exhibited the M macrolide resistance phenotype and the mefA/ermB genotype. Isolates were grouped into 2 clones on the basis of emm-MLST-PFGE-virulence gene profile combinations: clone 1, characterized by the combined genotype emm12-ST36-pulsotype A-speG; and clone 2, characterized by the genotype emm77-ST63-pulsotype B-speC. Our results do not show conclusively that animals may represent a new reservoir of S. pyogenes but indicate the ability of human-derived S. pyogenes isolates to colonize and infect animals. Vela AI, Villalón P, Sáez-Nieto JA, Chacón G, Domínguez L, Fernández-Garayzábal JF. Characterization of Streptococcus pyogenes from Animal Clinical Specimens, Spain. Emerg Infect Dis. 2017 Dec;23(12):2013-2016. 10.3201/eid2312.151146 1080-6059 1080-6040 Emerging infectious diseases 29148379 https://hdl.handle.net/20.500.12105/25977 Spain Streptococcus pyogenes Animals Antimicrobial resistance Bacteria Characterization Detection Erythromycin Genes Group A Streptococcus Streptococci Virulence Characterization of Streptococcus pyogenes from Animal Clinical Specimens, Spain