2026-04-29T06:16:18Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/259692025-12-18T12:57:23Zcom_20.500.12105_2273com_20.500.12105_2202col_20.500.12105_19571
Repisalud
author
Guijarro, Maria V
author
Leal, Juan F M
author
Fominaya, Jesus
author
Blanco-Aparicio, Carmen
author
Alonso, Soledad
author
Lleonart, Matilde
author
Castellvi, Josep
author
Ruiz, Lidia
author
Ramon Y Cajal, Santiago
author
Carnero, Amancio
2025-01-09T09:01:30Z
2025-01-09T09:01:30Z
2007-08
Carcinogenesis . 2007 Aug;28(8):1646-52.
https://hdl.handle.net/20.500.12105/25969
17426052
Carcinogenesis
We undertook a large-scale genetic screen to identify genes able to alter the cellular response to physiological signals and provide selective advantage once tumorigenesis has begun. We identified MAP17, a small 17 kDa non-glycosylated membrane protein previously identified, being overexpressed in carcinomas. We found that MAP17 is overexpressed in a great variety of human carcinomas. Immunohistochemical analysis of MAP17 during cancer progression shows, at least in prostate and ovarian carcinomas, that overexpression of the protein strongly correlates with tumoral progression (P < 0.0001). Many tumor cells also express MAP17 and its expression does not correlate with expression of SCL, a neighbor gene reported to be co-expressed in some hematopoietic cell lines. SCL neither is expressed in most MAP17-positive tumors, indicating the independent transcription of MAP17, at least in carcinomas. We cloned 5' genomic region to MAP17 and described the minimal promoter necessary to produce independent activation of MAP17. Moreover, we have found that MAP17 promoter is activated by oncogenes. Taken together, our data show an independent activation of MAP17 promoter that can be driven by oncogenes and that might explain the common overexpression of MAP17 in human carcinomas.
eng
TRANSCRIPTIONAL REGULATION
IDENTIFICATION
PROTEIN
GENETICS
SCL
MAP17 overexpression is a common characteristic of carcinomas.
research article
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URL
https://repisalud.isciii.es/bitstreams/9065b77d-1dd7-4025-ae6f-2a74d690dda8/download
File
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cceed7e1c20378a724d7270c48434f4a
1270856
application/pdf
map17overexpression-2017.pdf