2026-05-17T01:16:10Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/259652025-12-18T12:56:37Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Jacqueline Forget, Camille
author
Minetti, Corrado
author
Monzon-Fernandez, Sara
author
Silveira, Leonor
author
Cuesta de la Plaza, Isabel
author
Pista, Ângela
author
Herrera-León, Silvia
funder
Instituto de Salud Carlos III
funder
Unión Europea. European Centre for Disease Prevention and Control (ECDC)
2025-01-08T11:32:32Z
2025-01-08T11:32:32Z
2025
Jacqueline C, Minetti C, Monzon Fernandez S, Silveira L, Cuesta De La Plaza I, Pista Â, Herrera-Leon S. Genomic epidemiology of fluoroquinolone-resistant strains of Shigella sonnei and Shigella flexneri in the Iberian Peninsula from 2015 to 2022. J Infect Dis. 2025 Jun 2;231(5):1176-1185.
10.1093/infdis/jiae596
1537-6613
0022-1899
The Journal of infectious diseases
39611769
https://hdl.handle.net/20.500.12105/25965
Fluoroquinolone-resistance in Shigella is among the serious antimicrobial resistance (AMR) threats. We investigated the genomic epidemiology of fluoroquinolone resistant (FQR) strains of S. sonnei and S. flexneri from 2015 to 2022 in Spain and Portugal. We determined the AMR profiles of 416 isolates (S. flexneri and S. sonnei) and FQR isolates were subjected to whole-genome sequencing. The percentage of FQR isolates gradually increased to reach 38% and 80% of S. flexneri and S. sonnei isolates, respectively in 2022. S. sonnei isolates from men were significantly more likely to be FQR (RR = 4.9, 95% CI = 2.7- 9.0). Genomic analysis revealed two major genetic clusters of FQR S. sonnei from the CipR.MSM5 lineage, previously associated with extreme antimicrobial resistance and transmission in men having sex with men. This study contributes to a better understanding of FQR shigellosis transmission and highlights the added value of enhanced surveillance for these pathogens.
eng
Shigella flexneri
Shigella sonnei
Iberian Peninsula
Portugal
Spain
Antimicrobial resistance
Fluoroquinolones
Surveillance
Genomic epidemiology of fluoroquinolone-resistant strains of Shigella sonnei and Shigella flexneri in the Iberian Peninsula from 2015 to 2022
research article
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