2026-04-26T23:12:47Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/259582025-12-18T12:56:19Zcom_20.500.12105_2327com_20.500.12105_2290col_20.500.12105_16991
Repisalud
author
García-Silva, Susana
author
Benito-Martín, Alberto
author
Sánchez-Redondo, Sara
author
Hernández-Barranco, Alberto
author
Ximénez-Embún, Pilar
author
Nogués, Laura
author
Mazariegos, Marina S
author
Brinkmann, Kay
author
Amor López, Ana
author
Meyer, Lisa
author
Rodríguez, Carlos
author
García-Martín, Carmen
author
Boskovic, Jasminka
author
Letón, Rocío
author
Montero, Cristina
author
Robledo Batanero, Mercedes
author
Santambrogio, Laura
author
Sue Brady, Mary
author
Szumera-Ciećkiewicz, Anna
author
Kalinowska, Iwona
author
Skog, Johan
author
Noerholm, Mikkel
author
Muñoz, Javier
author
Ortiz-Romero, Pablo L
author
Ruano, Yolanda
author
Rodríguez-Peralto, José L
author
Rutkowski, Piotr
author
Peinado Selgas, Hector
funder
United States Department of Health & Human Services National Institutes of Health (NIH) - USA
funder
Feldstein Foundation
funder
Starr Cancer Consortium
funder
La Caixa Foundation
funder
Fundacion Cientifica Asociacion Espanola Contra el Cancer
funder
Ramon Areces Foundation
funder
Comunidad de Madrid (España)
funder
Ministerio de Ciencia y Competetividad (España)
2025-01-07T17:05:53Z
2025-01-07T17:05:53Z
2019-05-06
J Exp Med . 2019 May 6;216(5):1061-1070.
https://hdl.handle.net/20.500.12105/25958
30975894
Journal of Experimental Medicine
Liquid biopsies from cancer patients have the potential to improve diagnosis and prognosis. The assessment of surrogate markers of tumor progression in circulating extracellular vesicles could be a powerful non-invasive approach in this setting. We have characterized extracellular vesicles purified from the lymphatic drainage also known as exudative seroma (ES) of stage III melanoma patients obtained after lymphadenectomy. Proteomic analysis showed that seroma-derived exosomes are enriched in proteins resembling melanoma progression. In addition, we found that the mutation can be detected in ES-derived extracellular vesicles and its detection correlated with patients at risk of relapse.
eng
MUTANT KRAS
EXOXOME
DNA CELLS
Use of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and mutation.
research article
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URL
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6bf04f1127594681512c36ae37498947
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application/pdf
useofextracellularvesicles_2019.pdf