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oai:repisalud.isciii.es:20.500.12105/259442025-12-18T12:59:18Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16973

00925njm 22002777a 4500 dc Oliván-Blázquez, Bárbara author Bona-Otal, Marta author Méndez-López, Fátima author Lerma-Irureta, David author García-Izuel, Paula author Ibáñez-Ruiz, Jesús author Montolío, Alberto author Ruiz-Herreros, María author Godino, Javier author Jimeno-Beltran, Beatriz author Encabo-Berzosa, María Del Mar author Arenaz, Izaskun author Medel-Martínez, Ana author Casado-Vicente, Verónica author Coiras, Mayte author Tellería-Orriols, Carlos author Schoorlemmer, Jon author Magallón-Botaya, Rosa author 2024-09-20 Post-coronavirus disease condition (PCC) continues to affect many people globally, yet there remains a lack of diagnostic biomarkers to distinguish PCC from those recovered from acute COVID-19. This study compared biomarkers between two age- and gender-matched groups: PCC individuals and those recovered within three months of acute COVID-19 in 2020 ( = 85 each). Biomarkers were assessed 12-24 months after initial diagnosis, examining biochemical profiles, blood cell counts, coagulation status, antibody serology, lymphocyte populations, and cytokine levels. PCC individuals exhibited significant alterations in 49 of 167 markers, including K+ levels, αGAD antibodies, antithrombin III, insulin-like growth factor-binding protein 3 (IGFBP3), and interleukin-10 (IL-10). A panel of αGAD, IL-10, potassium levels, and CD16CD56 cell presence distinguished PCC individuals from recovered patients with >88% accuracy and <92% precision. Oliván-Blázquez B, Bona-Otal M, Méndez-López F, Lerma-Irureta D, García-Izuel P, Ibáñez-Ruiz J, Montolío A, Ruiz-Herreros M, Godino J, Jimeno-Beltran B, Encabo-Berzosa MDM, Arenaz I, Medel-Martínez A, Casado-Vicente V, Coiras M, Tellería-Orriols C, Schoorlemmer J, Magallón-Botaya R. Characterization model of the post COVID-19 condition based on immunological, biochemical, and cytokine markers. iScience. 2024 Aug 30;27(9):110839. 10.1016/j.isci.2024.110839 2589-0042 iScience 39318534 https://hdl.handle.net/20.500.12105/25944 Biochemistry Immunology Virology Characterization model of the post COVID-19 condition based on immunological, biochemical, and cytokine markers