2026-04-26T23:12:51Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/259432025-12-18T12:59:18Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Keighley, Caitlin
author
Kim, Hannah Yejin
author
Kidd, Sarah
author
Chen, Sharon C-A
author
Alastruey-Izquierdo, Ana
author
Dao, Aiken
author
Bongomin, Felix
author
Chiller, Tom
author
Wahyuningsih, Retno
author
Forastiero, Agustina
author
Al-Nuseirat, Adi
author
Beyer, Peter
author
Gigante, Valeria
author
Beardsley, Justin
author
Sati, Hatim
author
Morrissey, C Orla
author
Alffenaar, Jan-Willem
funder
Federal Ministry of Education, Science and Research (Austria)
funder
Federal Ministry of Education & Research (Alemania)
2025-01-07T13:09:01Z
2025-01-07T13:09:01Z
2024-06-27
Keighley C, Kim HY, Kidd S, Chen SC, Alastruey A, Dao A, Bongomin F, Chiller T, Wahyuningsih R, Forastiero A, Al-Nuseirat A, Beyer P, Gigante V, Beardsley J, Sati H, Morrissey CO, Alffenaar JW. Candida tropicalis-A systematic review to inform the World Health Organization of a fungal priority pathogens list. Med Mycol. 2024 Jun 27;62(6):myae040.
1369-3786
https://hdl.handle.net/20.500.12105/25943
38935905
10.1093/mmy/myae040
1460-2709
Medical mycology
In response to the growing global burden of fungal infections with uncertain impact, the World Health Organization (WHO) established an Expert Group to identify priority fungal pathogens and establish the WHO Fungal Priority Pathogens List for future research. This systematic review aimed to evaluate the features and global impact of invasive candidiasis caused by Candida tropicalis. PubMed and Web of Science were searched for studies reporting on criteria of mortality, morbidity (defined as hospitalization and disability), drug resistance, preventability, yearly incidence, diagnostics, treatability, and distribution/emergence from 2011 to 2021. Thirty studies, encompassing 436 patients from 25 countries were included in the analysis. All-cause mortality due to invasive C. tropicalis infections was 55%-60%. Resistance rates to fluconazole, itraconazole, voriconazole and posaconazole up to 40%-80% were observed but C. tropicalis isolates showed low resistance rates to the echinocandins (0%-1%), amphotericin B (0%), and flucytosine (0%-4%). Leukaemia (odds ratio (OR) = 4.77) and chronic lung disease (OR = 2.62) were identified as risk factors for invasive infections. Incidence rates highlight the geographic variability and provide valuable context for understanding the global burden of C. tropicalis infections. C. tropicalis candidiasis is associated with high mortality rates and high rates of resistance to triazoles. To address this emerging threat, concerted efforts are needed to develop novel antifungal agents and therapeutic approaches tailored to C. tropicalis infections. Global surveillance studies could better inform the annual incidence rates, distribution and trends and allow informed evaluation of the global impact of C. tropicalis infections.
eng
Candida tropicalis
Candidaemia
Global epidemiology
Invasive fungal infection
Mortality
Candida tropicalis-A systematic review to inform the World Health Organization of a fungal priority pathogens list.
review article
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URL
https://repisalud.isciii.es/bitstreams/bccb2acb-6951-4aec-a7b5-99653c2c11a0/download
File
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81f8f02e95b3b2f3d9e20fd25bc27bcb
954726
application/pdf
CandidaTropicalisSystematicReview_2024.pdf