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oai:repisalud.isciii.es:20.500.12105/259422025-12-18T12:59:03Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Ortega Martín, Javier author Agulló-Ros, Irene author Roy, Álvaro author Moreno-Iruela, Inmaculada author Gómez-Buendía, Alberto author Romero Martínez, Beatriz author Ferreras-Colino, Elisa author Juan Ferre, Lucia de author Dominguez-Rodriguez, Mercedes author Domínguez Rodríguez, Lucas author Risalde, María A author Bezos, J author 2024-12 Caprine livestock are significant reservoirs of the complex (MTBC), contributing to tuberculosis (TB) transmission among animals and humans. The P22 protein immunocomplex (P22PI), derived from bovine tuberculin, shows immunostimulating capacity and is used for TB diagnosis. This study assessed the immunogenicity and protective efficacy of P22PI in two groups of goats: 24 naïve goats (12 immunised, 12 controls) from a TB-free herd, and 24 infected goats (12 immunised, 12 controls), referred to as pre-infected animals, from a -infected herd. Both were exposed for 5 months to -naturally infected goats. Reactors to single and comparative intradermal tuberculin (SIT and SCIT, respectively) tests and interferon-gamma release assay (IGRA) significantly increased ( < 0.05) in both groups 5 months' post-exposure, with no significant differences between immunised and control animals. However, immunised animals exhibited a significantly higher ( < 0.05) antibody response against P22PI. Most naïve animals (83.3%) and all pre-infected animals developed TB-compatible lesions, with extensive necrosis in the lungs and associated lymph nodes, compared to 50% and 83.3% of control animals, respectively. These findings suggest that while P22PI stimulates an intense antibody response under the conditions of the present study, it does not confer protection against TB and may exacerbate disease severity. Ortega Martín, Javier; Agulló-Ros, Irene; Roy, Álvaro; Moreno-Iruela, Inmaculada; Gómez-Buendía, Alberto; Romero Martínez, Beatriz; Ferreras-Colino, Elisa; Juan Ferré, Lucia de; Dominguez-Rodriguez, Mercedes; Domínguez Rodríguez, Lucas; Risalde, María A; Bezos, J. A high titer antibody response against P22 protein immunocomplex is not correlated with protection in naturally tuberculosis-infected goats. Vet Q. 2024 Dec;44(1):16-30. 10.1080/01652176.2024.2429851 1875-5941 0165-2176 The veterinary quarterly 39558884 https://hdl.handle.net/20.500.12105/25942 P22 protein immunocomplex Tuberculosis Diagnosis Goat Immunisation Lesions A high titer antibody response against P22 protein immunocomplex is not correlated with protection in naturally tuberculosis-infected goats