2026-05-17T01:16:03Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/259342025-12-18T12:56:18Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608
Repisalud
author
Lopez-Cuadrado, Teresa
author
Ortiz Burgos, Cristina
author
Ayuso-Alvarez, Ana Maria
author
Galan, Iñaki
funder
Instituto de Salud Carlos III
2024-12-23T18:24:31Z
2024-12-23T18:24:31Z
2023
López-Cuadrado T, Ortiz C, Ayuso-Álvarez A, Galán I. Impact of psychological distress on mortality in Spain. The importance of early detection and treatment of mental disorders. J Psychiatr Res. 2023. doi: 10.1016/j.jpsychires.2023.11.045. Epub 2023 Dec 3. PMID: 38065054.
10.1016/j.jpsychires.2023.11.045
0022-3956
Journal of Psychiatric Research
38065054
https://hdl.handle.net/20.500.12105/25934
Background: Mental health problems account for 14% of mortality worldwide. The aim of this study was to evaluate the association between psychological distress and mortality in the Spanish adult population. Methods: Data came from a longitudinal study in population ≥15 years of age (n=21,005) who participated in the 2011-12 Spanish National Health Survey, which was linked to mortality records as of December 2020. Mental health was assessed with the GHQ-12, defining psychological distress as a dichotomous variable using a GHQ-12 score ≥3 as the cutoff point. Using Poisson regression, standardized mortality rate ratios (SRR) were estimated for all-cause, cardiovascular disease, and tumor-related mortality, adjusting for sociodemographic variables, lifestyles, and comorbidities. Results: The standardized overall mortality rate in individuals with and without psychological distress was 14.58 and 10.90 per 1000 person-years, respectively, estimating an SRR of 1.34 (95%CI: 1.19-1.50). The SRR for tumor-related mortality was 1.17 (95%CI: 0.90-1.53), and cardiovascular-related mortality was related to higher distress (GHQ-12 ≥ 4): SRR of 1.22 (95%CI: 0.98-1.51). Among psychological distressed individuals, the overall mortality SRR for those with a previous mental disorder diagnosis was 1.18 (95%CI: 0.91-1.53) versus 1.34 (95%CI: 1.18-1.54) for those without such diagnosis (p for interaction=0.067). Similarly, distressed participants taking prescription drugs for mental disorders had a lower mortality risk than those not taking them (p for interaction=0.016). Conclusions: Individuals with psychological distress had a higher risk of overall-, cardiovascular disease- and tumor-related mortality. This association was higher among participants not previously diagnosed with a mental disorder and those not taking medication for mental issues.
eng
Diagnosis
Mortality
Psychological distress
Treatment
Impact of psychological distress on mortality in Spain. The importance of early detection and treatment of mental disorders.
research article
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ImpactPsychologicalDistressMortalitySpain_2024.pdf
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Supplementary_ImpactPsychologicalDistressMortalitySpain_2024.pdf