2026-04-29T12:24:03Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/259012025-12-18T13:00:39Zcom_20.500.12105_19586com_20.500.12105_2202col_20.500.12105_19587

00925njm 22002777a 4500 dc de Frutos, Fernando author Saturi, Giulia author Gonzalez-Lopez, Esther author Sguazzotti, Maurizio author Dominguez, Fernando author Ponziani, Alberto author Cabrera-Romero, Eva author Caponetti, Angelo Giuseppe author Lozano, Sara author Massa, Paolo author Peiro-Aventin, Belen author Accietto, Antonella author Mora-Ayestarán, Nerea author Giovannetti, Alessandro author Castro-Urda, Victor author Gagliardi, Christian author Cobo-Marcos, Marta author Rios-Tamayo, Rafael author Biagini, Elena author Gomez-Bueno, Manuel author Galiè, Nazzareno author Segovia-Cubero, Javier author Longhi, Simone author Garcia-Pavia, Pablo author 2024-12 Although sudden death (SD) is a recognized complication of cardiac amyloidosis, there is scarce data about its incidence, mechanisms, and predictors. The aim of this study was to describe incidence of SD and to analyze possible risk factors. Consecutive patients with ATTR or AL cardiac amyloidosis evaluated at two European centers were identified. SD was defined as unexpected death in clinically stable patients. Cox proportional hazard regression was performed to assess risk factors in univariate analysis. Those statistically significant were then assessed through age-adjusted multivariate analysis. Analysis included 784 patients, 569 with ATTR amyloidosis (mean age 74.1 ± 12.1 years) and 215 with AL amyloidosis (mean age 64.5 ± 10.8 years). After a median follow-up of 1.9 years, SD rate at 2 years was 1.8% in ATTR. Previous pacemaker implantation (PPM) was associated with increased risk after age-adjusted analysis (HR 4.97; 95%CI: 1.39-17.7;  = 0.01). SD rate in AL amyloidosis patients at 2 years was 8.0% after a median follow-up of 1.2 years. Betablockers and NYHA III-IV were independently associated with an increased risk after age-adjusted multivariate analysis (HR 7.06 95%CI (2.31-21.5)  = 0.001) and (HR 4.56 95%CI (1.51-13.8)  = 0.007) respectively. SD is more frequent in AL than in ATTR cardiac amyloidosis. SD is associated with different risk factors in both entities. Amyloid. 2024 Dec;31(4):334-338. 39449197 https://hdl.handle.net/20.500.12105/25901 AL amyloidosis Amyloidosis Cardiomyopathies sudden death transthyretin amyloidosis Incidence and predictors of sudden death in patients with cardiac amyloidosis.