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oai:repisalud.isciii.es:20.500.12105/258792025-12-18T12:56:20Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Álvarez, Eva G author Demeulemeester, Jonas author Otero, Paula author Jolly, Clemency author García-Souto, Daniel author Pequeño-Valtierra, Ana author Zamora, Jorge author Tojo, Marta author Temes, Javier author Baez-Ortega, Adrian author Rodriguez-Martin, Bernardo author Oitaben, Ana author Bruzos, Alicia L author Martínez-Fernández, Mónica author Haase, Kerstin author Zumalave, Sonia author Abal, Rosanna author Rodríguez-Castro, Jorge author Rodriguez-Casanova, Aitor author Diaz-Lagares, Angel author Li, Yilong author Raine, Keiran M author Butler, Adam P author Otero, Iago author Ono, Atsushi author Aikata, Hiroshi author Chayama, Kazuaki author Ueno, Masaki author Hayami, Shinya author Yamaue, Hiroki author Maejima, Kazuhiro author Blanco, Miguel G author Forns, Xavier author Rivas, Carmen author Ruiz-Bañobre, Juan author Pérez-Del-Pulgar, Sofía author Torres-Ruiz, Raul author Rodriguez Perales, Sandra author Garaigorta, Urtzi author Tubio, Jose M C author Campbell, Peter J author Nakagawa, Hidewaki author Van Loo, Peter author 2021-11-25 Most cancers are characterized by the somatic acquisition of genomic rearrangements during tumour evolution that eventually drive the oncogenesis. Here, using multiplatform sequencing technologies, we identify and characterize a remarkable mutational mechanism in human hepatocellular carcinoma caused by Hepatitis B virus, by which DNA molecules from the virus are inserted into the tumour genome causing dramatic changes in its configuration, including non-homologous chromosomal fusions, dicentric chromosomes and megabase-size telomeric deletions. This aberrant mutational mechanism, present in at least 8% of all HCC tumours, can provide the driver rearrangements that a cancer clone requires to survive and grow, including loss of relevant tumour suppressor genes. Most of these events are clonal and occur early during liver cancer evolution. Real-time timing estimation reveals some HBV-mediated rearrangements occur as early as two decades before cancer diagnosis. Overall, these data underscore the importance of characterising liver cancer genomes for patterns of HBV integration. Nat Commun . 2021 Nov 25;12(1):6910. Nature Communications 34824211 https://hdl.handle.net/20.500.12105/25879 READ ALIGNMENT LIVER TRANSLOCATION CHROMOSOMES ASSOCIATION MUTATIONS Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture.