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00925njm 22002777a 4500 dc Valiente, Manuel author Ahluwalia, Manmeet S author Boire, Adrienne author Brastianos, Priscilla K author Goldberg, Sarah B author Lee, Eudocia Q author Le Rhun, Emilie author Preusser, Matthias author Winkler, Frank author Soffietti, Riccardo author 2018-03 Metastasis, involving the spread of systemic cancer to the brain, results in neurologic disability and death. Current treatments are largely palliative in nature; improved therapeutic approaches represent an unmet clinical need. However, recent experimental and clinical advances challenge the bleak long-term outcome of this disease. Encompassing key recent findings in epidemiology, genetics, microenvironment, leptomeningeal disease, neurocognition, targeted therapy, immunotherapy, and prophylaxis, we review preclinical and clinical studies to provide a comprehensive picture of contemporary research and the management of secondary brain tumors. Trends Cancer . 2018 Mar;4(3):176-196 Trends in Cancer https://pmc.ncbi.nlm.nih.gov/articles/PMC6602095/pdf/nihms-1037277.pdf 29506669 https://hdl.handle.net/20.500.12105/25875 brain metastasis genomics microenvironment neurocognition prevention therapy The Evolving Landscape of Brain Metastasis.