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oai:repisalud.isciii.es:20.500.12105/258602025-12-18T13:00:57Zcom_20.500.12105_19586com_20.500.12105_2202col_20.500.12105_19587

00925njm 22002777a 4500 dc Jiménez-Fernández, María author de la Fuente, Hortensia author Martín, Pilar author Cibrián, Danay author Sánchez-Madrid, Francisco author 2023 CD69 is an early leukocyte activation marker involved in the regulation of the immune response. Initial studies evaluated its function using monoclonal antibodies until knock-out mice were developed. Subsequently, four ligands for CD69 have been identified, namely galectin-1, S100A8/S100A9 complex, myosin light chains 9 and 12, and oxidized low-density lipoproteins. In addition, several molecules are laterally associated with and regulated by CD69, including calreticulin and two transmembrane receptors, sphingosine-1-phosphate receptor (S1P1) and the heterodimeric amino acid transporter complex SLC7A5-SLC3A2 (LAT1-CD98). Recently, CD69 engagement has been shown to induce the expression of the immunoregulatory receptor programmed cell death-1 (PD-1) in T cells. The molecular signaling induced by CD69 has been explored in different scenarios and cell types. This review provides a perspective on the molecular pathways, ligands and cellular functions known to be regulated by CD69. EXCLI J. 2023 Mar 16:22:334-351. https://hdl.handle.net/20.500.12105/25860 37223078 Experimental and Clinical Sciences Journal CD69 CD69-ligands CD69-signaling molecular signaling-pathway Unraveling CD69 signaling pathways, ligands and laterally associated molecules.