2026-05-17T01:16:09Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/258572025-12-18T12:56:18Zcom_20.500.12105_2273com_20.500.12105_2202col_20.500.12105_19571
Repisalud
author
Jablonska, Paola Anna
author
Bosch-Barrera, Joaquim
author
Serrano, Diego
author
Valiente, Manuel
author
Calvo, Alfonso
author
Aristu, Javier
2024-12-04T13:19:16Z
2024-12-04T13:19:16Z
2021-04-29
Cancers (Basel) . 2021 Apr 29;13(9):2141.
Cancers (Basel)
33946751
https://hdl.handle.net/20.500.12105/25857
Approximately 20% patients with non-small cell lung cancer (NSCLC) present with CNS spread at the time of diagnosis and 25-50% are found to have brain metastases (BMs) during the course of the disease. The improvement in the diagnostic tools and screening, as well as the use of new systemic therapies have contributed to a more precise diagnosis and prolonged survival of lung cancer patients with more time for BMs development. In the past, most of the systemic therapies failed intracranially because of the inability to effectively cross the blood brain barrier. Some of the new targeted therapies, especially the group of tyrosine kinase inhibitors (TKIs) have shown durable CNS response. However, the use of ionizing radiation remains vital in the management of metastatic brain disease. Although a decrease in CNS-related deaths has been achieved over the past decade, many challenges arise from the need of multiple and repeated brain radiation treatments, which carry along not insignificant risks and toxicity. The combination of stereotactic radiotherapy and systemic treatments in terms of effectiveness and adverse effects, such as radionecrosis, remains a subject of ongoing investigation. This review discusses the challenges of the use of radiation therapy in NSCLC BMs in view of different systemic treatments such as chemotherapy, TKIs and immunotherapy. It also outlines the future perspectives and strategies for personalized BMs management.
eng
animal models
brain metastases
non-small cell lung cancer
proton beam therapy
radionecrosis
stereotactic radiosurgery
targeted therapies
Challenges and Novel Opportunities of Radiation Therapy for Brain Metastases in Non-Small Cell Lung Cancer.
research article
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URL
https://repisalud.isciii.es/bitstreams/81ea403f-7e27-4daf-9d9f-c7c1f5aa3cbc/download
File
MD5
8d5caa2538c49610a8a6928d1ecd25db
882554
application/pdf
ChallengesandNovelOpportunitiesofRadiation-2021.pdf