2026-04-29T23:03:58Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/258512025-12-18T12:56:50Zcom_20.500.12105_19586com_20.500.12105_2202col_20.500.12105_19587
Repisalud
author
Hernansanz-Agustín, Pablo
author
Enríquez, José Antonio
funder
Ministerio de Economía y Competitividad (España)
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación ProCNIC
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2024-12-04T10:54:20Z
2024-12-04T10:54:20Z
2023-01-01
Biochim Biophys Acta Bioenerg. 2023 Jan 1;1864(1):148936.
Biochimica et Biophysica Acta. Bioenergetics.
36395975
https://hdl.handle.net/20.500.12105/25851
Oxidative phosphorylation is a common process to most organisms in which the main function is to generate an electrochemical gradient across the inner mitochondrial membrane (IMM) and to make energy available to the cell. However, plants, many fungi and some animals maintain non-energy conserving oxidases which serve as a bypass to coupled respiration. Namely, the alternative NADH:ubiquinone oxidoreductase NDI1, present in the complex I (CI)-lacking Saccharomyces cerevisiae, and the alternative oxidase, ubiquinol:oxygen oxidoreductase AOX, present in many organisms across different kingdoms. In the last few years, these alternative oxidases have been used to dissect previously indivisible processes in bioenergetics and have helped to discover, understand, and corroborate important processes in mitochondria. Here, we review how the use of alternative oxidases have contributed to the knowledge in CI stability, bioenergetics, redox biology, and the implications of their use in current and future research.
eng
AOX
Alternative oxidase
CoQ pool
Oxphos
ROS
Alternative respiratory oxidases to study the animal electron transport chain.
research article
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URL
https://repisalud.isciii.es/bitstreams/24d729ed-6100-48d0-b784-5d2669b6c811/download
File
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ef27dbe71af2ff39a7e1e7c8ba83fe87
1520236
application/pdf
Alternative respiratory_Biochim Biophys Acta Bioenerg_2023.pdf