2026-08-29T14:17:43Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/258502025-12-18T13:00:55Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
García-Poyatos, Carolina
author
Arora, Prateek
author
Calvo, Enrique
author
Marques, Ines J
author
Kirschke, Nick
author
Galardi-Castilla, Maria
author
Lembke, Carla
author
Meer, Marco
author
Fernández-Montes, Paula
author
Ernst, Alexander
author
Haberthür, David
author
Hlushchuk, Ruslan
author
Vázquez, Jesús
author
Vermathen, Peter
author
Enríquez, José Antonio
author
Mercader, Nadia
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Unión Europea. Comisión Europea. H2020
funder
Unión Europea. Comisión Europea. NextGenerationEU
funder
Plan de Recuperación, Transformación y Resiliencia (España)
funder
Centro de Investigación Biomédica en Red - CIBERFES (Fragilidad y Envejecimiento Saludable)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fondation Leducq
funder
Instituto de Salud Carlos III
funder
Comunidad de Madrid (España)
funder
Fundación La Caixa
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2024-12-04T10:42:20Z
2024-12-04T10:42:20Z
2024-07-22
Dev Cell. 2024 Jul 22;59(14):1824-1841.e10.
Developmental Cell
38701784
https://hdl.handle.net/20.500.12105/25850
The oxidative phosphorylation (OXPHOS) system is intricately organized, with respiratory complexes forming super-assembled quaternary structures whose assembly mechanisms and physiological roles remain under investigation. Cox7a2l, also known as Scaf1, facilitates complex III and complex IV (CIII-CIV) super-assembly, enhancing energetic efficiency in various species. We examined the role of Cox7a1, another Cox7a family member, in supercomplex assembly and muscle physiology. Zebrafish lacking Cox7a1 exhibited reduced CIV formation, metabolic alterations, and non-pathological muscle performance decline. Additionally, cox7a1 hearts displayed a pro-regenerative metabolic profile, impacting cardiac regenerative response. The distinct phenotypic effects of cox7a1 and cox7a2l underscore the diverse metabolic and physiological consequences of impaired supercomplex formation, emphasizing the significance of Cox7a1 in muscle maturation within the OXPHOS system.
eng
Ca(2+) signaling
cox7a1
cox7a2l
electron transport chain
heart regeneration
metabolic rewiring
mitochondria
muscle physiology
scaf1
supercomplex assembly
zebrafish
Cox7a1 controls skeletal muscle physiology and heart regeneration through complex IV dimerization.
research article
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URL
https://repisalud.isciii.es/bitstreams/2c233bf4-1b04-463f-a9ab-3c3382dbc837/download
File
MD5
b32b2cd9e80f1800e78ae778ddcaed51
8168901
application/pdf
Cox7a1 controls skeletal muscle_Dev Cell_2024.pdf