2026-05-22T01:40:58Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/258502025-12-18T13:00:55Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc García-Poyatos, Carolina author Arora, Prateek author Calvo, Enrique author Marques, Ines J author Kirschke, Nick author Galardi-Castilla, Maria author Lembke, Carla author Meer, Marco author Fernández-Montes, Paula author Ernst, Alexander author Haberthür, David author Hlushchuk, Ruslan author Vázquez, Jesús author Vermathen, Peter author Enríquez, José Antonio author Mercader, Nadia author 2024-07-22 The oxidative phosphorylation (OXPHOS) system is intricately organized, with respiratory complexes forming super-assembled quaternary structures whose assembly mechanisms and physiological roles remain under investigation. Cox7a2l, also known as Scaf1, facilitates complex III and complex IV (CIII-CIV) super-assembly, enhancing energetic efficiency in various species. We examined the role of Cox7a1, another Cox7a family member, in supercomplex assembly and muscle physiology. Zebrafish lacking Cox7a1 exhibited reduced CIV formation, metabolic alterations, and non-pathological muscle performance decline. Additionally, cox7a1 hearts displayed a pro-regenerative metabolic profile, impacting cardiac regenerative response. The distinct phenotypic effects of cox7a1 and cox7a2l underscore the diverse metabolic and physiological consequences of impaired supercomplex formation, emphasizing the significance of Cox7a1 in muscle maturation within the OXPHOS system. Dev Cell. 2024 Jul 22;59(14):1824-1841.e10. Developmental Cell 38701784 https://hdl.handle.net/20.500.12105/25850 Ca(2+) signaling cox7a1 cox7a2l electron transport chain heart regeneration metabolic rewiring mitochondria muscle physiology scaf1 supercomplex assembly zebrafish Cox7a1 controls skeletal muscle physiology and heart regeneration through complex IV dimerization.