2026-05-17T01:15:43Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/258282025-12-18T12:56:20Zcom_20.500.12105_19586com_20.500.12105_2202col_20.500.12105_19587
Repisalud
author
Moreno-Arciniegas, Andrea
author
Cádiz, Laura
author
Galán-Arriola, Carlos
author
Clemente-Moragón, Agustín
author
Ibáñez, Borja
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Unión Europea. Comisión Europea. H2020
funder
Comunidad de Madrid
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Red Madrileña de Nanomedicina en Imagen Molecular
funder
Instituto de Salud Carlos III
funder
Fundación ProCNIC
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2024-11-29T16:15:10Z
2024-11-29T16:15:10Z
2024-09-09
Basic Res Cardiol. 2024 Sep 9.
Basic Research in Cardiology
39249555
https://hdl.handle.net/20.500.12105/25828
Thanks to the fantastic progress in cancer therapy options, there is a growing population of cancer survivors. This success has resulted in a need to focus much effort into improving the quality of life of this population. Cancer and cardiovascular disease share many common risk factors and have an interplay between them, with one condition mechanistically affecting the other and vice versa. Furthermore, widely prescribed cancer therapies have known toxic effects in the cardiovascular system. Anthracyclines are the paradigm of efficacious cancer therapy widely prescribed with a strong cardiotoxic potential. While some cancer therapies cardiovascular toxicities are transient, others are irreversible. There is a growing need to develop cardioprotective therapies that, when used in conjunction with cancer therapies, can prevent cardiovascular toxicity and thus improve long-term quality of life in survivors. The field has three main challenges: (i) identification of the ultimate mechanisms leading to cardiotoxicity to (ii) identify specific therapeutic targets, and (iii) more sensible diagnostic tools to early identify these conditions. In this review we will focus on the cardioprotective strategies tested and under investigation. We will focus this article into anthracycline cardiotoxicity since it is still the agent most widely prescribed, the one with higher toxic effects on the heart, and the most widely studied.
eng
Anthracyclines
Cardio-oncology
Cardioprotection
Cardiotoxicity
Cardioprotection strategies for anthracycline cardiotoxicity.
review article
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URL
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505c98a443707694c8903703193564d1
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Cardioprotection strategies_Basic Res Cardiol_2024.pdf