2026-04-29T00:59:51Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/258262025-12-18T13:00:21Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Ramos-Prada, Alba author Redondo-Rodríguez, Andrés author Roca-Luque, Ivo author Porta-Sánchez, Andreu author Ter Bekke, Rachel M A author Quintanilla, Jorge G author Sánchez-González, Javier author Peinado, Rafael author Merino, Jose Luis author Cluitmans, Matthijs author Holtackers, Robert J author Marina-Breysse, Manuel author Galán-Arriola, Carlos author Enríquez-Vázquez, Daniel author Vázquez-Calvo, Sara author Alfonso-Almazán, José Manuel author Pizarro, Gonzalo author Ibáñez, Borja author González-Ferrer, Juan José author Salgado-Aranda, Ricardo author Cañadas-Godoy, Victoria author Calvo, David author Pérez-Villacastín, Julián author Pérez-Castellano, Nicasio author Filgueiras-Rama, David author 2024-10-03 There is lack of agreement on late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) imaging processing for guiding ventricular tachycardia (VT) ablation. We aim at developing and validating a systematic processing approach on LGE-CMR images to identify VT corridors that contain critical VT isthmus sites. This is a translational study including 18 pigs with established myocardial infarction and inducible VT undergoing in vivo characterization of the anatomical and functional myocardial substrate associated with VT maintenance. Clinical validation was conducted in a multicentre series of 33 patients with ischaemic cardiomyopathy undergoing VT ablation. Three-dimensional LGE-CMR images were processed using systematic scanning of 15 signal intensity (SI) cut-off ranges to obtain surface visualization of all potential VT corridors. Analysis and comparisons of imaging and electrophysiological data were performed in individuals with full electrophysiological characterization of the isthmus sites of at least one VT morphology. In both the experimental pig model and patients undergoing VT ablation, all the electrophysiologically defined isthmus sites (n = 11 and n = 19, respectively) showed overlapping regions with CMR-based potential VT corridors. Such imaging-based VT corridors were less specific than electrophysiologically guided ablation lesions at critical isthmus sites. However, an optimized strategy using the 7 most relevant SI cut-off ranges among patients showed an increase in specificity compared to using 15 SI cut-off ranges (70 vs. 62%, respectively), without diminishing the capability to detect VT isthmus sites (sensitivity 100%). Systematic imaging processing of LGE-CMR sequences using several SI cut-off ranges may improve and standardize procedure planning to identify VT isthmus sites. https://hdl.handle.net/20.500.12105/25826 39298664 Europace Imaging processing Magnetic resonance imaging Radiofrequency ablation Ventricular tachycardia Novel systematic processing of cardiac magnetic resonance imaging identifies target regions associated with infarct-related ventricular tachycardia.