2026-04-26T23:12:00Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/258072025-12-18T12:56:22Zcom_20.500.12105_19586com_20.500.12105_2202col_20.500.12105_19587
Repisalud
author
Tristão-Pereira, Catarina
author
Fuster, Valentin
author
Lopez-Jimenez, Alejandro
author
Fernández-Pena, Alberto
author
Semerano, Aurora
author
Fernandez-Nueda, Irene
author
Garcia-Lunar, Ines
author
Ayuso, Carmen
author
Sanchez-Gonzalez, Javier
author
Ibanez, Borja
author
Gispert, Juan Domingo
author
Cortes-Canteli, Marta
author
Tristão-Pereira, Catarina
author
Fuster, Valentin
author
Lopez-Jimenez, Alejandro
author
Fernández-Pena, Alberto
author
Semerano, Aurora
author
Fernandez-Nueda, Irene
author
Garcia-Lunar, Ines
author
Ayuso, Carmen
author
Sanchez-Gonzalez, Javier
author
Ibanez, Borja
author
Gispert, Juan Domingo
author
Cortes-Canteli, Marta
funder
Banco Santander
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
funder
Fundación La Caixa
funder
Fundación ProCNIC
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
2024-11-28T14:35:22Z
2024-11-28T14:35:22Z
2024-12
Am Heart J. 2024 Dec:278:195-207.
https://hdl.handle.net/20.500.12105/25807
39322173
American Heart Journal
Cognitive decline and dementia have been reportedly linked to atherosclerosis, the main cause of cardiovascular disease. Cohort studies identifying early brain alterations associated with subclinical atherosclerosis are warranted to understand the potential of prevention strategies before cerebral damage becomes symptomatic and irreversible. The Progression of Early Subclinical Atherosclerosis (PESA) study is a longitudinal observational cohort study that recruited 4,184 asymptomatic middle-aged individuals (40-54 years) in 2010 in Madrid (Spain) to thoroughly characterize subclinical atherosclerosis development over time. In this framework, the PESA-Brain study has been designed to identify early structural, functional and vascular brain changes associated with midlife atherosclerosis and cardiovascular risk factors. The PESA-Brain study targets 1,000 participants at the 10-year follow-up PESA visit and consists of thorough neuropsychological testing, advanced multimodal neuroimaging, and quantification of blood-based neuropathological biomarkers. We hypothesize that, in middle-age, the presence of cardiovascular risk factors and a high burden of subclinical atherosclerosis will be associated with structural, functional and vascular brain alterations, greater amyloid burden and subtle cognitive impairment. We further hypothesize that the link between subclinical atherosclerosis and poor brain health in midlife will be mediated by cerebrovascular pathology and intracranial atherosclerosis. Enrollment dates: The PESA-Brain study started in October 2020 and is estimated to be completed by December 2024.
Conclusion: This study is in a unique position to unveil novel relationships between cardiovascular and brain alterations in the health-to-disease transition, which may have important implications for interventional and therapeutic approaches.
eng
Subclinical atherosclerosis and brain health in midlife: Rationale and design of the PESA-Brain study.
review article
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URL
https://repisalud.isciii.es/bitstreams/21793fcf-dcb6-45fc-ade5-42cce14894a0/download
File
MD5
904294bc80d36d111b5efa52acf5ce64
1622076
application/pdf
Subclinical atherosclerosis_Am Heart J_2024.pdf