2026-07-22T05:26:28Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/257982025-12-18T12:56:04Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Orbegozo-Medina, R A
author
Martínez-Sernández, V
author
Folgueira, I
author
Mezo, M
author
González-Warleta, M
author
Perteguer-Prieto, Maria Jesus
author
Romarís, F
author
Leiro, J M
author
Ubeira, Florencio M
funder
Ministerio de Economía y Competitividad (España)
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Xunta de Galicia (España)
2024-11-22T14:02:58Z
2024-11-22T14:02:58Z
2019-02
Mol Immunol. 2019 Feb:106:1-11.
10.1016/j.molimm.2018.11.019
1872-9142
0161-5890
Molecular immunology
30572282
https://hdl.handle.net/20.500.12105/25798
Peptide vaccines constitute an interesting alternative to classical vaccines due to the possibility of selecting specific epitopes, easy of production and safety. However, an inadequate design may render these peptides poorly immunogenic or lead to undesirable outcomes (e.g., formation of B neoepitopes). As an approach to vaccine development, we evaluated the antibody response to chimeras composed of two or three known B epitopes from Trichinella and Fasciola, and several linkers (GSGSG, GPGPG and KK) in species as different as mice, sheep and turbot. All these species could mount an effective immune response to the short chimeric peptides. Nevertheless, this response depended on several factors including a favorable orientation of B-cell epitopes, adequateness of linkers and/or probability of formation of T neoepitopes. We also observed that, at least in mice, the inclusion of a decoy epitope may have favorable consequences on the antibody response to other epitopes in the chimera.
eng
Antibodies
Antigen
Chimeric peptide
Epitope linker
Fasciola
Vaccine
Antibody responses to chimeric peptides derived from parasite antigens in mice and other animal species
research article
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