2026-05-17T01:16:10Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/255342025-12-18T12:56:38Zcom_20.500.12105_2273com_20.500.12105_2202col_20.500.12105_19571
Repisalud
author
Zheng, Di
author
Pisano, Filippo
author
Collard, Liam
author
Balena, Antonio
author
Pisanello, Marco
author
Spagnolo, Barbara
author
Mach-Batlle, Rosa
author
Tantussi, Francesco
author
Carbone, Luigi
author
De Angelis, Francesco
author
Valiente, Manuel
author
de la Prida, Liset M
author
Ciracì, Cristian
author
De Vittorio, Massimo
author
Pisanello, Ferruccio
funder
European Union (EU)
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
National Institutes of Health (NIH) - USA
2024-11-19T12:47:15Z
2024-11-19T12:47:15Z
2023-03
Adv Mater . 2023 Mar;35(11):e2200902.
Advanced Materials
36479741
https://hdl.handle.net/20.500.12105/25534
Integration of plasmonic nanostructures with fiber-optics-based neural probes enables label-free detection of molecular fingerprints via surface-enhanced Raman spectroscopy (SERS), and it represents a fascinating technological horizon to investigate brain function. However, developing neuroplasmonic probes that can interface with deep brain regions with minimal invasiveness while providing the sensitivity to detect biomolecular signatures in a physiological environment is challenging, in particular because the same waveguide must be employed for both delivering excitation light and collecting the resulting scattered photons. Here, a SERS-active neural probe based on a tapered optical fiber (TF) decorated with gold nanoislands (NIs) that can detect neurotransmitters down to the micromolar range is presented. To do this, a novel, nonplanar repeated dewetting technique to fabricate gold NIs with sub-10 nm gaps, uniformly distributed on the wide (square millimeter scale in surface area), highly curved surface of TF is developed. It is experimentally and numerically shown that the amplified broadband near-field enhancement of the high-density NIs layer allows for achieving a limit of detection in aqueous solution of 10 m for rhodamine 6G and 10 m for serotonin and dopamine through SERS at near-infrared wavelengths. The NIs-TF technology is envisioned as a first step toward the unexplored frontier of in vivo label-free plasmonic neural interfaces.
eng
gold nanoislands
gold-nanoparticles-decorated tapered fibers
label-free detection
neurotransmitters
plasmonics
solid-state dewetting
tapered fibers
Toward Plasmonic Neural Probes: SERS Detection of Neurotransmitters through Gold-Nanoislands-Decorated Tapered Optical Fibers with Sub-10 nm Gaps.
research article
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URL
https://repisalud.isciii.es/bitstreams/8584c9d3-5c4a-4cb8-a1b5-e520dc681ef3/download
File
MD5
84934224311a625b7159eeacb93c82e7
3787815
application/pdf
TowardPlasmonicNeuralProbes-2022.pdf