2026-06-14T05:06:09Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/255322025-12-18T12:57:22Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Sanchez-Aguilera, Alberto author Masmudi-Martín, Mariam author Navas-Olive, Andrea author Baena, Patricia author Hernández-Oliver, Carolina author Priego, Neibla author Cordón-Barris, Lluís author Alvaro-Espinosa, Laura author García, Santiago author Martinez, Sonia author Lafarga, Miguel author Lin, Michael Z author Al-Shahrour, Fatima author Menendez de la Prida, Liset author Valiente, Manuel author 2023-09-11 A high percentage of patients with brain metastases frequently develop neurocognitive symptoms; however, understanding how brain metastasis co-opts the function of neuronal circuits beyond a tumor mass effect remains unknown. We report a comprehensive multidimensional modeling of brain functional analyses in the context of brain metastasis. By testing different preclinical models of brain metastasis from various primary sources and oncogenic profiles, we dissociated the heterogeneous impact on local field potential oscillatory activity from cortical and hippocampal areas that we detected from the homogeneous inter-model tumor size or glial response. In contrast, we report a potential underlying molecular program responsible for impairing neuronal crosstalk by scoring the transcriptomic and mutational profiles in a model-specific manner. Additionally, measurement of various brain activity readouts matched with machine learning strategies confirmed model-specific alterations that could help predict the presence and subtype of metastasis. Cancer Cell . 2023 Sep 11;41(9):1637-1649.e11. Cancer Cell 37652007 https://hdl.handle.net/20.500.12105/25532 biomarkers brain circuit impact brain metastasis cancer neuroscience decision trees electrophysiology elta oscillations gamma oscillations Machine learning identifies experimental brain metastasis subtypes based on their influence on neural circuits.