2026-05-22T01:39:14Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/255042025-12-18T12:55:44Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Jibreel, Tayseer author Khogali, Altayeb author Jimenez, Maribel author Raiyed, Adeel author Dakein, Osman author Alsharif, Bashir author Khalid, Noteila M author Osman, Omran F author Nour, Bakri Y M author Mohamed, Gamal Hassan author Molina, Ricardo author Vidal-López, Ana author Díaz-Regañón, Ramón author den Boer, Margriet author Alvar, Jorge author Courtenay, Orin author Elnaiem, Dia-Eldin author 2023-12 Visceral leishmaniasis (VL, kala azar), caused by Leishmania donovani, transmitted by Phlebotomus orientalis, is a serious systemic disease that causes high morbidity and mortality rates in Sudan and other parts of East Africa and the world. Despite progress in understanding the epidemiology of the disease in East Africa, little is known about the host preference of P. orientalis in kala azar endemic villages of Sudan, which have some of the highest VL incidence rates in the world. The present study used host choice experiments and blood-meal identification approaches to determine the host preference of P. orientalis in kala azar endemic villages in Gedarif state, eastern Sudan. In the host choice experiment, tent traps were used to compare the attractiveness of cows, donkeys, sheep and goats for host-seeking P. orientalis. In the blood-meal identification study, blood-fed P. orientalis females, captured inside houses and peri-domestic habitats, were subjected to molecular typing using cytochrome b gene (cyt b) amplification and sequence analysis. Cows and donkeys were the most attractive to blood-seeking P. orientalis, followed by goats. Similarly, the blood-meal analysis of P. orientalis showed that the vector preferentially feeds on cows, followed by donkeys, humans and goats. The human blood index of P. orientalis was 19.4% (42/216), indicating a high zoophilic habit of the vector, both inside and outside the houses. Although the order of host preference varied by location, it was clear that cows are the most preferred host of P. orientalis in the area. Results are discussed in relation to the role of domestic/livestock animals in VL zoopotentiation and zooprophylaxis. Inference is made on the potential impact of insecticide treatment of cows in control of the vector and the transmission of VL in Sudan and other parts of East Africa. Med Vet Entomol. 2023 Dec;37(4):782-792. 10.1111/mve.12683 1365-2915 0269-283X Medical and veterinary entomology 37540228 https://hdl.handle.net/20.500.12105/25504 Phlebotomus orientalis Cattle Control Host preference Human blood index Livestock Sand flies Visceral leishmaniasis Host preference and human blood index of Phlebotomus orientalis, an exophilic sand fly vector of visceral leishmaniasis in eastern Sudan