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oai:repisalud.isciii.es:20.500.12105/255022025-12-18T12:55:52Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Monge, Susana author García-Ortúzar, Visitación author López Hernández, Begoña author Lopaz Pérez, María Ángeles author Delacour-Estrella, Sarah author Sánchez-Seco, María Paz author Fernandez Martinez, Beatriz author García San Miguel, Lucía author García-Fulgueiras, Ana author Sierra Moros, María José author Dengue Outbreak Investigation Team author Vázquez González author Vazquez, Ana author Molina, Ricardo author De Ory, Fernando de author Jimenez, Maribel author 2020-05 On October 3rd 2018, dengue virus (DENV) infection was confirmed in three family members (symptoms onset between August 18th and 27th) without travel history outside of Spain. They had been together in the Autonomous Communities (AC) of Murcia and Andalusia. By the end of October, a second cluster of two dengue cases (symptoms onset on September 27th and 30th) was confirmed in the AC of Murcia. DENV type 1 sequence was identical to the first cluster, and the epidemiological link was a visit from a case of the first cluster to a fruit-farm neighboring the small village of residence of the second cluster. The entomological investigation found Aedes albopictus activity in this area although all mosquitoes were PCR-negative for DENV. This is the first autochthonous dengue outbreak identified in Spain. This outbreak highlights challenges to timely detect and respond to DENV transmission and opens questions on dengue dynamics in a non-endemic context. Acta Trop. 2020 May:205:105402. 10.1016/j.actatropica.2020.105402 1873-6254 0001-706X Acta tropica 32088276 https://hdl.handle.net/20.500.12105/25502 Aedes Autochthonous transmission Dengue Dengue virus Disease outbreaks Europe Spain Characterization of the first autochthonous dengue outbreak in Spain (August-September 2018)