2026-04-29T12:23:46Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/254922025-12-18T13:00:42Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Yuste, Eloisa
author
Gil, Horacio
author
García, Felipe
author
Sanchez-Merino, Victor
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia e Innovación (España)
funder
Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas)
2024-11-12T12:35:11Z
2024-11-12T12:35:11Z
2024-10-17
Vaccines (Basel). 2024 Oct 17;12(10):1176.
10.3390/vaccines12101176
2076-393X
Vaccines (Basel)
39460342
https://hdl.handle.net/20.500.12105/25492
Background/objectives: The impact of virion maturation on neutralizing antibody responses in HIV treatment is not fully understood. This study examines whether antiretroviral regimens (ART) with boosted protease inhibitors (b-PI), which increase exposure to immature virions, affect neutralization capacity compared to Non-b-PI regimens. Methods: Neutralization activity was assessed in 45 HIV-infected individuals on b-PI regimens and 56 on Non-b-PI regimens, adjusting for factors like infection duration, ART initiation, and immune markers. Individuals on b-PI regimens had significantly lower neutralization scores [mean: 6.1, 95% Confidence Interval (CI): 5.3-6.9] than those on Non-b-PI regimens (mean: 8.9, 95% CI: 8.0-9.9; p < 0.0001). This difference was not explained by infection duration or CD4+ counts. CD4+/CD8+ ratios were positively associated with neutralization, while b-PI use was negatively associated. A regression model indicated that b-PI use significantly predicted lower neutralization scores (beta = -0.30, p = 0.049). Conclusions: These findings suggest that exposure to immature virions via b-PI use reduces neutralizing antibody responses, highlighting the importance of virion maturation in antibody induction. ART regimens promoting exposure to mature virions may enhance neutralization, with potential implications for HIV vaccine design. Further research is needed to explore implications for HIV vaccine design, especially using virus-like particles.
eng
ART
Broadly neutralizing antibodies
HIV-1
Boosted protease inhibitors
Undetectable viremia
Antiretroviral Therapy with Ritonavir-Boosted Atazanavir- and Lopinavir-Containing Regimens Correlates with Diminished HIV-1 Neutralization.
research article
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URL
https://repisalud.isciii.es/bitstreams/9cd7f791-7431-4a5f-a5df-8ddd38558241/download
File
MD5
a8dc3d6c39052e0be883079c6d2a40da
910606
application/pdf
AntiretroviralTherapyRitonavir-Boosted_2024.pdf