2026-05-20T04:01:37Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/254382025-12-18T12:56:23Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_19609col_20.500.12105_16963col_20.500.12105_16988
Repisalud
author
Gonzalez Blazquez, Cristina
author
Torres, Montserrat
author
Benito, Amparo
author
Del Romero, Jorge
author
Rodríguez, Carmen
author
Fontillón, María
author
Trastoy, Mónica
author
Viciana, Pompeyo
author
Amo, Julia del
author
Ortiz Rivera, Marta
author
Hernández-Novoa, Beatriz
author
CoRIS-HPV Study Group
2024-11-06T08:12:31Z
2024-11-06T08:12:31Z
2013-09-01
Int J Cancer. 2013 Sep 1;133(5):1164-72.
10.1002/ijc.28102
1097-0215
0020-7136
International journal of cancer
23404769
https://hdl.handle.net/20.500.12105/25438
The aim of our study was to determine the baseline prevalence of anal squamous intraepithelial lesions (SIL) and associated risk factors in HIV-infected men who have sex with men (MSM) in a Spanish ongoing multicenter cohort. CoRIS-HPV started in 2007, nested in the Spanish AIDS Research Network Cohort (CoRIS). Anal liquid cytology testing was performed. High-risk human papillomavirus (HR-HPV) infection was determined, and positive samples were genotyped. We analyzed all subjects up to April 2011. Multivariate logistic regression analyses were performed. A total of 551 subjects with baseline anal liquid cytologies were analyzed; 37.0% negative for intraepithelial lesion, 9.0% atypical squamous cells of uncertain significance (ASCUS), 41.0% low-grade SIL, 4.0% high-grade SIL and 9.0% inadequate. Prevalence of anal SIL (excluding ASCUS) in valid samples (n = 450) was 54.7% (95% confidence interval [CI] = 49.9-59.3). Globally HR-HPV prevalence was 81.7% (95% CI = 78.0-85.2). Multiple infections (≥2 HR-HPV genotypes) were documented in 77.7% (95% CI = 73.1-82.0). The only risk factor associated with anal SIL was the number of HR-HPV types; MSM with five or more HR-HPV genotypes had an odds ratio (OR) of anal SIL seven times greater (OR = 7.4; 95% CI = 2.8-19.6) than those with one HR-HPV genotype. No associations were found for age, educational level, smoking, geographical origin, CD4 T-cell count, antiretroviral treatment or number of sexual partners. The prevalence of anal SIL in young HIV-positive MSM is high, and the main risk factor is multiple infections with HR-HPV types.
eng
HIV
HPV
Anal
Cytology
Squamous intraepithelial lesion
Anal squamous intraepithelial lesions are frequent among young HIV-infected men who have sex with men followed up at the Spanish AIDS Research Network Cohort (CoRIS-HPV)
research article
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AnalSquamousIntraepithelialLesions_Accepted_2013.pdf