2026-08-29T14:15:13Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/253782025-12-18T12:56:57Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Virseda-Berdices, Ana
author
Behar-Lagares, Raquel
author
Martínez-González, Oscar
author
Blancas, Rafael
author
Bueno-Bustos, Soraya
author
Brochado-Kith, Oscar
author
Manteiga, Eva
author
Mallol Poyato, María J
author
López Matamala, Blanca
author
Martín Parra, Carmen
author
Resino, Salvador
author
Jimenez-Sousa, Maria Angeles
author
Fernandez-Rodriguez, Amanda
funder
Instituto de Salud Carlos III
funder
Fundación Universidad Alfonso X el Sabio
funder
Banco Santander
funder
Unión Europea. Comisión Europea. NextGenerationEU
funder
Ministerio de Ciencia e Innovación (España)
funder
Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas)
2024-10-30T11:34:21Z
2024-10-30T11:34:21Z
2024-08-07
Crit Care. 2024 Aug 7;28(1):267.
10.1186/s13054-024-05051-6
1466-609X
1364-8535
Crit Care
39113075
https://hdl.handle.net/20.500.12105/25378
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes virus-induced-senescence. There is an association between shorter telomere length (TL) in coronavirus disease 2019 (COVID-19) patients and hospitalization, severity, or even death. However, it remains unknown whether virus-induced-senescence is reversible. We aim to evaluate the dynamics of TL in COVID-19 patients 1 year after recovery from intensive care units (ICU). Longitudinal study enrolling 49 patients admitted to ICU due to COVID-19 (August 2020 to April 2021). Relative telomere length (RTL) quantification was carried out in whole blood by monochromatic multiplex real-time quantitative PCR (MMqPCR) assay at hospitalization (baseline) and 1 year after discharge (1-year visit). The association between RTL and ICU length of stay (LOS), invasive mechanical ventilation (IMV), prone position, and pulmonary fibrosis development at 1-year visit was evaluated. The median age was 60 years, 71.4% were males, median ICU-LOS was 12 days, 73.5% required IMV, and 38.8% required a prone position. Patients with longer ICU-LOS or who required IMV showed greater RTL shortening during follow-up. Patients who required pronation had a greater RTL shortening during follow-up. IMV patients who developed pulmonary fibrosis showed greater RTL reduction and shorter RTL at the 1-year visit. Patients with longer ICU-LOS and those who required IMV had a shorter RTL in peripheral blood, as observed 1 year after hospital discharge. Additionally, patients who required IMV and developed pulmonary fibrosis had greater telomere shortening, showing shorter telomeres at the 1-year visit. These patients may be more prone to develop cellular senescence and lung-related complications; therefore, closer monitoring may be needed.
eng
ARDS
COVID-19
ICU
IMV
Relative telomere length
SARS-CoV2
Longer ICU stay and invasive mechanical ventilation accelerate telomere shortening in COVID-19 patients 1 year after recovery
research article
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Longer_ICU_StayInvasiveMechanicalVentilation_2024.pdf.txt
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