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00925njm 22002777a 4500 dc Serrano-Benítez, Almudena author Cortes-Ledesma, Felipe author Ruiz, Jose F author 2020-01-10 Endogenously-arising DNA double-strand breaks (DSBs) rarely harbor canonical 5'-phosphate, 3'-hydroxyl moieties at the ends, which are, regardless of the pathway used, ultimately required for their repair. Cells are therefore endowed with a wide variety of enzymes that can deal with these chemical and structural variations and guarantee the formation of ligatable termini. An important distinction is whether the ends are directly "unblocked" by specific enzymatic activities without affecting the integrity of the DNA molecule and its sequence, or whether they are "processed" by unspecific nucleases that remove nucleotides from the termini. DNA end structure and configuration, therefore, shape the repair process, its requirements, and, importantly, its final outcome. Thus, the molecular mechanisms that coordinate and integrate the cellular response to blocked DSBs, although still largely unexplored, can be particularly relevant for maintaining genome integrity and avoiding malignant transformation and cancer. Front Mol Biosci . 2020 Jan 10:6:153. https://hdl.handle.net/20.500.12105/25324 31998749 Front Mol Biosci ATM DNA double strand break (DSB) DNA-PK catalytic subunit Non-homologous DNA end joining genome instability "An End to a Means": How DNA-End Structure Shapes the Double-Strand Break Repair Process.