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oai:repisalud.isciii.es:20.500.12105/253162025-12-18T13:00:42Zcom_20.500.12105_2273com_20.500.12105_2202col_20.500.12105_19571

00925njm 22002777a 4500 dc Andradas, Clara author Blasco-Benito, Sandra author Castillo-Lluva, Sonia author Dillenburg-Pilla, Patricia author Diez-Alarcia, Rebeca author Juanes-García, Alba author García-Taboada, Elena author Hernando-Llorente, Rodrigo author Soriano, Joaquim author Hamann, Sigrid author Wenners, Antonia author Alkatout, Ibrahim author Klapper, Wolfram author Rocken, Christoph author Bauer, Maret author Arnold, Norbert author Quintanilla, Miguel author Megías, Diego author Vicente-Manzanares, Miguel author Urigüen, Leyre author Gutkind, J Silvio author Guzmán, Manuel author Pérez-Gómez, Eduardo author Sánchez, Cristina author 2016-07-26 The orphan G protein-coupled receptor GPR55 has been directly or indirectly related to basic alterations that drive malignant growth: uncontrolled cancer cell proliferation, sustained angiogenesis, and cancer cell adhesion and migration. However, little is known about the involvement of this receptor in metastasis. Here, we show that elevated GPR55 expression in human tumors is associated with the aggressive basal/triple-negative breast cancer population, higher probability to develop metastases, and therefore poor patient prognosis. Activation of GPR55 by its proposed endogenous ligand lysophosphatidylinositol confers pro-invasive features on breast cancer cells both in vitro and in vivo. Specifically, this effect is elicited by coupling to Gq/11 heterotrimeric proteins and the subsequent activation, through ERK, of the transcription factor ETV4/PEA3. Together, these data show that GPR55 promotes breast cancer metastasis, and supports the notion that this orphan receptor may constitute a new therapeutic target and potential biomarker in the highly aggressive triple-negative subtype. Oncotarget . 2016 Jul 26;7(30):47565-47575 https://hdl.handle.net/20.500.12105/25316 27340777 Oncotarget G protein-coupled receptor GPR55 cannabinoids metastasis triple-negative breast cancer Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast cancer.