2026-05-01T03:39:46Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/252862024-10-23T13:07:25Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16938col_20.500.12105_16958col_20.500.12105_16970
Repisalud author Juncal-Ruiz, Maria author Riesco-Davila, Laura author Vazquez-Bourgon, Javier author Ortiz-Garcia de la Foz, Victor author Mayoral-Van Son, Jacqueline author Ayesa-Arriola, Rosa author Setien-Suero, Esther author Leza, Juan Carlos author Lopez-Hoyos, Marcos author Crespo-Facorro, Benedicto 2024-10-23T13:07:25Z 2024-10-23T13:07:25Z 2020-08-25 10.3390/ijms21176106 1422-0067 International journal of molecular sciences http://hdl.handle.net/10668/16165 32854231 https://hdl.handle.net/20.500.12105/25286 Toll-like receptors (TLRs) are a pivotal component of the innate immune system that seem to have a role in the pathogenesis of psychosis. The purpose of this work was to compare the expression and functionality of 9 TLRs in three peripheral blood mononuclear cells (PBMCs) (monocytes, B cells, and T cells) between 33 drug-naïve first-episode psychosis (FEP) individuals and 26 healthy volunteers, at baseline and after 3-month of antipsychotic treatment. The expression of TLRs 1-9 were assessed by flow cytometry. For the assessment of the TLR functionality, cells collected in sodium heparin tubes were polyclonally stimulated for 18 h, with different agonists for human TLR1-9. The results of our study highlight the role that TLR5 and TLR8 might play in the pathophysiology of psychosis. We found a lower expression of these receptors in FEP individuals, regarding healthy volunteers at baseline and after 3-month of treatment on the three PBMCs subsets. Most TLRs showed a lower functionality (especially reduced intracellular levels of TNF-α) in patients than in healthy volunteers. These results, together with previous evidence, suggest that individuals with psychosis might show a pattern of TLR expression that differs from that of healthy volunteers, which could vary according to the intensity of immune/inflammatory response. eng Cytokines Neuroinflammation Psychosis Toll-like receptors Expression and Functionality Study of 9 Toll-Like Receptors in 33 Drug-Naïve Non-Affective First Episode Psychosis Individuals: A 3-Month Study research article