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00925njm 22002777a 4500 dc Martín-Bórnez, Marta author Galeano-Otero, Isabel author Del Toro, Raquel author Smani, Tarik author Martín-Bórnez, Marta author Galeano-Otero, Isabel author Del Toro, Raquel author Smani, Tarik author 2020-08-25 Transient receptor potentials (TRPs) are non-selective cation channels that are widely expressed in vascular beds. They contribute to the Ca2+ influx evoked by a wide spectrum of chemical and physical stimuli, both in endothelial and vascular smooth muscle cells. Within the superfamily of TRP channels, different isoforms of TRPC (canonical) and TRPV (vanilloid) have emerged as important regulators of vascular tone and blood flow pressure. Additionally, several lines of evidence derived from animal models, and even from human subjects, highlighted the role of TRPC and TRPV in vascular remodeling and disease. Dysregulation in the function and/or expression of TRPC and TRPV isoforms likely regulates vascular smooth muscle cells switching from a contractile to a synthetic phenotype. This process contributes to the development and progression of vascular disorders, such as systemic and pulmonary arterial hypertension, atherosclerosis and restenosis. In this review, we provide an overview of the current knowledge on the implication of TRPC and TRPV in the physiological and pathological processes of some frequent vascular diseases. 10.3390/ijms21176125 1422-0067 International journal of molecular sciences http://hdl.handle.net/10668/16166 32854408 https://hdl.handle.net/20.500.12105/25282 TRPC TRPV Vascular disease Vascular remodeling Vascular tone TRPC and TRPV Channels' Role in Vascular Remodeling and Disease.