2026-07-22T09:51:01Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/252792024-10-23T13:07:23Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16958
Repisalud author Cruz-Chamorro, Ivan author Álvarez-Sánchez, Nuria author Santos-Sánchez, Guillermo author Pedroche, Justo author Fernández-Pachón, María-Soledad author Millán, Francisco author Millán-Linares, María Carmen author Lardone, Patricia Judith author Bejarano, Ignacio author Guerrero, Juan Miguel author Carrillo-Vico, Antonio 2024-10-23T13:07:23Z 2024-10-23T13:07:23Z 2020-06-04 10.3390/nu12061673 2072-6643 Nutrients http://hdl.handle.net/10668/15698 32512720 https://hdl.handle.net/20.500.12105/25279 Peptides from several plant food proteins not only maintain the nutritional values of the original protein and decrease the environmental impact of animal agriculture, but also exert biological activities with significant health-beneficial effects. Wheat is the most important food grain source in the world. However, negative attention on wheat-based products has arose due to the role of gluten in celiac disease. A controlled enzymatic hydrolysis could reduce the antigenicity of wheat gluten protein hydrolysates (WGPHs). Therefore, the aims of the present study were to evaluate the effects of the in vitro administration of Alcalase-generated WGPHs on the immunological and antioxidant responses of human peripheral blood mononuclear cells (PBMCs) from 39 healthy subjects. WGPH treatment reduced cell proliferation and the production of the Type 1 T helper (Th1) and Th17 pro-inflammatory cytokines IFN-? and IL-17, respectively. WPGHs also improved the cellular anti-inflammatory microenvironment, increasing Th2/Th1 and Th2/Th17 balances. Additionally, WGPHs improved global antioxidant capacity, increased levels of the reduced form of glutathione and reduced nitric oxide production. These findings, not previously reported, highlight the beneficial capacity of these vegetable protein hydrolysates, which might represent an effective alternative in functional food generation. eng Antioxidant capacity Bioactive peptides Glutathione Oxidative stress Peripheral blood mononuclear cells Pro-inflammatory cytokines Wheat gluten protein hydrolysates Immunomodulatory and Antioxidant Properties of Wheat Gluten Protein Hydrolysates in Human Peripheral Blood Mononuclear Cells. research article